Título del artículo:

Diet and Clinical Outcomes in a Heart Failure Population

Background There are limited data to inform dietary recommendations in persons with heart failure (HF). Objectives The aim of this study was to examine associations between consumption levels of 11 common foods, and a healthy diet pattern, with clinical outcomes in a HF population. Methods This analysis was a substudy of 3,798 participants from 25 countries enrolled in the multinational G-CHF (Global Congestive Heart Failure) registry with dietary data collected through food frequency questionnaires. Associations were examined between consumption levels of 6 plant-based foods (fruits, vegetables, legumes, nuts, whole grains, and refined grains) and 5 animal-based foods (fish, poultry, unprocessed red meat, eggs, and dairy) with the primary composite outcome of death or HF hospitalization and its components. Also examined was the association between an overall healthy diet pattern (measured by using a mAHEI [modified Alternative Heathy Eating Index]) and these outcomes. Results A total of 1,236 participants had a primary outcome event, 890 participants died, and 593 were hospitalized for HF. Higher legume intake (HR: 0.85 [95% CI: 0.73-0.99] for 0.1 to <0.5 serving per day and HR: 0.80 [95% CI: 0.65-0.98] for ≥0.5 serving per day vs <0.1 serving per day) was associated with a lower risk of the primary outcome. Moderate vegetable intake (1 to <3 servings per day) was associated with a lower risk of HF hospitalization (HR: 0.77 [95% CI: 0.61-0.97]) compared with <1 serving per day. Higher refined grain intake was associated with a higher risk of hospitalization for HF (HR: 1.56 [95% CI: 1.19-2.05] for 1-3 servings per day and HR: 1.76 [95% CI: 1.30-2.39) for >3 servings per day vs <1 serving per day). Associations with other foods, as well as with the mAHEI, were neutral. Conclusions In persons with HF, higher legume and vegetable intake were each associated with a lower risk of adverse clinical outcomes, whereas higher refined grain intake was associated with a higher risk of adverse clinical outcomes.

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Jacc Heart Failure

Título del artículo:

Effect of Vitamin D on Chronic Obstructive Pulmonary Disease: A Systematic Review of Randomized Controlled Trials

Objective: To evaluate the clinical and biological effects of vitamin D supplementation in patients with chronic obstructive pulmonary disease, based on evidence from randomized controlled trials. Materials and Methods: A systematic review was conducted in accordance with the PRISMA guidelines. Three databases (PubMed/MEDLINE, Scopus, and Web of Science) were searched for randomized controlled trials published until June 2025. Studies were included if they assessed the effects of vitamin D supplementation in patients with chronic obstructive pulmonary disease and reported clinical or biological outcomes. Results: Twelve randomized controlled trials involving 6626 participants from diverse regions, with wide variability in sample sizes (36 to 5 110 participants). Most studies targeted patients with baseline vitamin D deficiency and evaluated varied dosing strategies (daily, weekly, monthly, or single high-dose regimens). Supplementation significantly increased serum 25(OH) D levels in all trials. Symptom burden and exacerbation frequency were reduced in most studies, particularly among patients with vitamin D deficiency. Consistent reductions in inflammatory markers, including IL-6, IL-8, and CRP, were observed. However, findings on pulmonary function (e.g., FEV1) and quality of life were mixed and often not statistically significant. Eleven studies (91.7 %) were classified as high methodological quality, and six (50 %) met high reporting standards. Conclusions: Vitamin D supplementation appears to offer clinical and biological benefits in COPD, particularly in patients with documented deficiency. Consistent findings across high-quality trials support its role in reducing symptoms and inflammation. However, its impact on lung function and long-term outcomes remains uncertain.

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Gaceta Medica De Caracas

Título del artículo:

Adult Rome IV Disorders of Gut–Brain Interaction in a Pediatric Population †

Background: Disorders of the gut–brain interaction (DGBIs) constitute a group of functional conditions widely described in adults; however, some of these have not been included in pediatric Rome criteria, despite the fact that they may manifest during childhood. Early identification of these conditions is relevant due to their clinical/psychosocial impact as well as their effect on quality of life. The aim was to determine the prevalence and associated factors of some DGBIs described in adults according to the Rome IV criteria in pediatric population. Methods: An observational/prospective/cross-sectional study was conducted in toddlers, school-aged children, and adolescents from three Colombian cities. The adapted Questionnaire for Pediatric Gastrointestinal Symptoms Rome IV (QPGS-IV) using adult criteria was applied, along with quality-of-life scales and PROMIS for anxiety/depression. Descriptive uni/bivariate analyses were performed as well as a multivariate logistic regression model. Results: A total of 704 participants were included (13.7 ± 2.8 years old). The prevalence of DGBIs described in adults according to QPGS-IV was 5.8%, with proctalgia fugax being the most frequent. In the bivariate analysis, race, school/social absenteeism, depressive traits, and impaired quality of life were significantly associated. In the multivariate model depressive traits (OR = 4.08; 95%CI = 1.82–9.12; p = 0.001), school (OR = 2.51; 95%CI = 1.06–5.98; p = 0.036), and social absenteeism (OR = 4.04; 95%CI = 1.70–9.62; p = 0.002) were the factors independently associated. Conclusions: These adult DGBIs, according to the QPGS-IV, can occur in pediatric populations and are closely related to psycho-emotional and functional factors. These are mainly associated with depression and school/social absenteeism, supporting the need for a biopsychosocial approach and a revision of the pediatric diagnostic criteria.

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Children

Título del artículo:

Economic burden of Chagas disease in Latin American countries: a population-based cost-of-illness analysis from the RAISE study

SummaryBackgroundChagas disease (ChD) remains a public health concern in Latin America. Despite a decline in overall prevalence, the chronic symptomatic forms still impose a substantial epidemiological and economic burden. This study undertakes a comprehensive, population-based cost analysis of chronic Chagas disease (CCD) from a societal perspective in seven endemic Latin American countries for 2010 and 2023.MethodsA Markov model with one-year cycles and six states was employed. Direct medical and indirect costs, converted to 2024 purchasing power parity US dollars, were estimated using prevalence data from the Global Burden of Disease Study 2023. Based on a previous Brazilian Markov model, parameters were adjusted using healthcare coverage and per capita health expenditure ratios for each country, further validated by national experts.FindingsIn 2010, Brazil (US$252 billion) and Argentina (US$164 billion) had the highest lifetime burdens. As a percentage of annual Gross Domestic Product, Bolivia (0·9%) and Argentina (0·8%) were most affected. CCD accounted for 6% of total health expenditures in both countries. Between 2010 and 2023, most countries experienced a decline in economic burden due to decreased CCD prevalence, despite an increased proportion of patients with cardiac conditions, reflecting population aging and disease progression.InterpretationCCD imposes substantial economic burden across Latin American countries. Epidemiological shift to older populations with severe cardiac forms signals increased healthcare demands. Findings inform policymakers for resource allocation and tailored interventions.FundingFunding was provided by Novartis Pharma AG as part of a research collaboration with the World Heart Federation (project number CLCZ696D2010R).

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Lancet Regional Health Americas

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Agreement in the Degree of Foraminal Stenosis Between Oblique Sagittal and Axial Sequences on Magnetic Resonance Imaging of the Lower Cervical Spine

Background Cervical foraminal stenosis is a common cause of radiculopathy, and its assessment by magnetic resonance imaging is typically performed using orthogonal planes, which may limit evaluation of the neural foramen due to its oblique orientation. Oblique sagittal sequences provide visualisation more closely aligned with the foraminal axis. Objective To assess agreement in the grading of foraminal stenosis between oblique sagittal and axial magnetic resonance imaging sequences of the lower cervical spine in patients with a history of cervicalgia. Materials and methods A prospective observational analytical study was conducted in 50 adult patients (400 neural foramina). The degree of foraminal stenosis from C4/C5 to C7/T1 was assessed using the Park classification for oblique sagittal sequences and the Kim classification, adapted by institutional consensus, for axial sequences. Intraobserver agreement between the two sequences was evaluated using Cohen\'s weighted kappa coefficient, interpreted according to Landis and Koch criteria. Additionally, the Stuart–Maxwell test was applied to identify systematic differences in the classification of stenosis severity between the two sequences. Results The mean age was 58.8 ± 12 years (range: 28–88), and 31 patients (62.0%) were women. The highest degree of stenosis was observed at C4/C5 and C5/C6. A higher grade of foraminal stenosis was identified on oblique sagittal sequences compared with axial sequences. Overall agreement was substantial to almost perfect at left C4/C5, right C6/C7, and left C7/T1 levels, with kappa values ranging from 0.81 to 0.92. The Stuart–Maxwell test showed a statistically significant difference (p < 0.001), with a tendency for the axial plane to classify a lower degree of severity. Conclusions Oblique sagittal and axial sequences show high agreement in the evaluation of cervical foraminal stenosis. However, a systematic difference in severity categorisation was identified, with axial sequences tending to assign lower stenosis grades. The inclusion of oblique sagittal sequences may be useful as a complementary technique in patients with a clinical suspicion of radiculopathy.

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Radiologia

Título del artículo:

Incidence, evolution and clinical behavior of pseudocholelithiasis associated with ceftriaxone in children

Ceftriaxone-associated pseudocholelithiasis is common but underdiagnosed in children, occurring in up to half of those receiving ceftriaxone. Although self-limiting, it is frequently accompanied by symptoms. OBJECTIVE: To report the incidence, course, risk factors, and clinical behavior of pseudocholelithiasis in children receiving ceftriaxone. PATIENTS AND METHOD: Prospective, descriptive, observational case series study. Patients aged 1 month to 18 years who received ceftriaxone were included. Clinical follow-up and hepatobiliary ultrasound were performed at the start of treatment and every 5 days until complete resolution. Association with risk factors was explored. Statistics used included Pearson\'s chi-square test and Fisher\'s exact test. RESULTS: Eighty patients were included, 51.2% were male, median age 4.5 years (range 5 months to 17 years). The prevalence of pseudocholelithiasis was 35% (28 patients), documented in 6 and 27 patients during the first and second ultrasound (21.4% and 96.4%). Pseudocholelithiasis was significantly more frequent in the age group older than 5 years, those with lower fluid intake, obese, overweight, and very rare in malnourished patients (all p < 0.05). Twelve patients presented abdominal pain as a cardinal symptom (42.9%). The mean duration of the stones was 19.1 (5-44) days. CONCLUSION: Ceftriaxone-associated pseudocholelithiasis is common, occurring in 1 out of 3 children who receive it. Its main risk factors were age over 5 years, lower fluid intake, overweight, and obesity. Abdominal pain is frequent, and the progression was self-limited.

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Andes Pediatrica Revista Chilena De Pediatria

Título del artículo:

Impact of emerging technologies on education: A systematic review

With technological advances in different areas, we have seen how education has been significantly transformed, improving teaching methods, facilitating different processes, and extending knowledge to people who previously would not have had access to it. This study conducts a systematic review of the impact and effects of emerging technologies on education over the last decade. To carry out this review, relevant studies are selected that address emerging technologies in education and their impact on learning, the challenges faced in implementing emerging technologies in education, and the evaluation of educational institutions\' experience in using information systems.

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Congreso Internacional De Innovacion Y Tendencias En Ingenieria Coniiti

Título del artículo:

Electrochemical Evaluation in Artificial Saliva of Orthodontic Brackets Recycled by Electrolytic Polished, Flamed and Sandblasting

In the present study the surface qualities of the orthodontic stainless austenitic steel brackets, modified through techniques commonly used in its recycling, specifically, the techniques of sandblasting and direct flamed were compared with a new technique of surface modification known as electropolishing with passivation. Through electrochemical tests such as Electrochemical Impedance Spectroscopy (EIS), Tafel extrapolation and cyclic potentiodynamic polarization all the corrosion processes for the material were evaluated in simulated physical medium, it means the mouth cavity. This one was simulated through an electrolytic assembly with three electrodes and one experimental physiological medium composed by artificial saliva Afnor at 37 °C. The results gathered evidenced that sandblasting produced the best protection qualities towards corrosion in the simulated mouth environment. The electropolishing technique and passivation showed good characteristics regards to the direct flaming brackets. However, sandblasting technique showed the best results in the specimen tested. Based on the facts previously mentioned, the recycling of metallic brackets at the surface level is an issue of great importance in the current orthodoncy field due to the fact that recycling presents important variables which influence the strength of adhesion to the teeth and the liberation of ions into the body.

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Journal of Bio and Tribo Corrosion

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Energy Integration and Valorization of Surplus Electricity Through Alkaline Water Electrolysis Within a Self-Generation Scheme Using Gas Turbogenerators

This study assesses the technical, operational, environmental, and economic feasibility of integrating alkaline water electrolysis (AEL) using on-site measured surplus electricity from two 20 MW natural-gas turbogenerators installed at a Central Processing Facility (CPF) in a Colombian oilfield. Unlike approaches based on modeled profiles, the analysis relies on more than 31,000 experimental records of gas consumption and active power, enabling an accurate characterization of the structural availability of energy surpluses under real operating conditions. A specialized industrial water treatment and purification company was consulted and provided with the physicochemical characterization results obtained from process water samples analyzed by an accredited laboratory. Based on these parameters, the technical supplier confirmed the feasibility of designing a multistage treatment train, including equalization, filtration, clarification, activated carbon, ultrafiltration, and reverse osmosis, capable of achieving final conductivities at or below 5 µS/cm. This water quality level is compatible with typical industrial alkaline electrolysis requirements and in line with technical specifications commonly aligned with ASTM and ISO standards for pressurized AEL systems. A strategic comparison between PEM and AEL technologies, supported by IFE/EFE matrices and sensitivity analyses, identified alkaline electrolysis as the optimal alternative under a stable electrical profile and capital expenditure constraints. Energy sizing for scenarios between 1.5 and 10 MW, assuming continuous 24 h operation and an average specific consumption of 50 kWh/kg H2, yields productions between 0.5 and 3.5 t H2/day, with electrical efficiencies above 70%. A 20-year financial analysis indicates a techno-economic threshold near 3 MW (NPV > 0; IRR > WACC), with optimal performance in the 6.5–10 MW range and payback periods between 2 and 4 years under internal valorization of the surplus electricity. From an environmental perspective, the produced hydrogen is classified as low-carbon rather than “green” due to its thermal origin; however, the integration improves the turbines’ operating regime and valorizes surplus electrical exergy that was previously unused, providing a replicable strategy for industrial assets with self-generation and treatable water availability.

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Sci

Título del artículo:

Relevance of Epstein-Barr Virus (EBV) miRNAs in EBV-Infected B Cells and B-Cell Lymphomas

Viral infection is a critical early event in Epstein–Barr virus (EBV)-positive B-cell lymphomas. While latent EBV proteins are known to promote cancer development, the role of EBV-encoded microRNAs (miRNAs) is not yet clear. These miRNAs are reported to regulate viral persistence, immune evasion, B-cell survival, and growth. This review compiles evidence on the role of EBV miRNAs in B cells and B-cell lymphomas, including their known target genes, and their effects on cancer-related pathways. By combining profiling studies and results from laboratory models, we highlight how EBV miRNAs might contribute to lymphoma development. Overall, this review provides a comprehensive overview of the biology of EBV-positive B-cell lymphoma, and current knowledge supports a critical role for EBV miRNAs in B cell transformation.

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Cancers

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Corrigendum to “Unravelling the past of cervid populations on the Pearl Island Archipelago (Panama) through a two dimensional geometric morphometric analysis of the lower third molar” [J. Archaeol. Sci. Volume 177, 106187]

The authors regret that following publication of the article, two of the originally listed co-authors, Anneke van Heteren and Gertrud Rößner, have requested that their names be removed from the author list, as they did not have an opportunity to approve the final, revised version. The corresponding author confirms that the revisions were conducted in good faith and accepts full responsibility for the final published content. With this corrigendum, the author list is updated to: María Fernanda Martínez-Polanco, Thomas Ingicco, Iván Rey-Rodríguez, Sergio Andrés Castro Méndez, Máximo Jiménez-Acosta, Juan Guillermo Martín. The corresponding author would like to apologise for any inconvenience caused. The authors would like to apologise for any inconvenience caused.

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Journal of Archaeological Science

Título del artículo:

Forecasting biomass hydrogen production using a novel recency-weighted grey multivariate model

The scalable production of green hydrogen from biomass gasification is hindered by unpredictable yields arising from complex, non-linear interactions among multiple feedstock and process parameters, compounded by sparse data in pilot-scale operations. Existing machine learning models demand large datasets, while traditional grey system models lack adaptability to recent information and multivariate dependencies. This study introduces a novel recency-weighted grey multivariate model incorporating a data preference accumulation operation with exponential weighting controlled by memory factor to dynamically prioritize recent observations. Integrated into a multivariable grey framework, it captures interdependencies while maintaining robustness with small samples. Theoretical stability analysis shows enhanced noise resistance in limited-data regimes. Validated on real-world biomass gasification data with 23 data points, the novel model achieves high accuracy with 0.096% mean absolute percentage error, 0.046 root mean square error and coefficient of determination of 0.9907. The prediction robustness is confirmed by Diebold-Mariano and superior prediction ability tests over some grey models, statistical models, and machine learning benchmarks. This first application of recency-weighted grey multivariate forecasting to biomass hydrogen production provides a data-efficient, interpretable tool for optimizing reactor operation and feedstock selection, accelerating the transition to a sustainable hydrogen economy.

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Renewable Energy

Título del artículo:

Comparative Prognosis of Chagas and Other Cardiomyopathies

AbstractBackgroundChagas disease, caused by Trypanosoma cruzi parasites, is a common cause of heart failure (HF) in Latin America and has recently been declared endemic in the United States. The authors compared outcomes in Chagasic HF vs ischemic and other nonischemic etiologies of HF with reduced ejection fraction (HFrEF).ObjectivesThe aim of this study was to compare clinical outcomes of Chagasic HFrEF vs ischemic and other nonischemic etiologies.MethodsInvestigator-reported etiology of HFrEF in the ATMOSPHERE, PARADIGM-HF, and GALACTIC-HF trials was categorized as ischemic, valvular, alcoholic, hypertensive, idiopathic, viral, Chagasic, or “other.” Time to the composite of first HF hospitalization or cardiovascular death, its components, all-cause death, and stroke was analyzed using Cox models adjusted for baseline characteristics, patient setting, trial, and other potential confounders.ResultsAmong 23,647 patients (13,381 ischemic, 4,344 idiopathic, 2,559 hypertensive, 1,923 others, 423 alcoholic, 412 valvular, 297 viral, and 308 Chagasic), Chagasic HF had the highest incidence rates of all clinical outcomes compared with other etiologies. Compared with patients with ischemic etiology, the adjusted HRs in Chagasic HF were significantly higher for the composite outcome (HR: 1.65; 95% CI: 1.36-2.02), HF hospitalization (HR: 1.75; 95% CI: 1.36-2.25), cardiovascular death (HR: 1.86; 95% CI: 1.47-2.35), all-cause death (HR: 1.82; 95% CI: 1.47-2.25), and stroke (HR: 2.16; 95% CI: 1.20-3.88).ConclusionsPatients with Chagasic HFrEF have a distinct clinical course associated not only with excess mortality but also with an increased risk for stroke compared with other etiologies except for valvular and “other” etiologies. (Aliskiren Trial to Minimize Outcomes in Patients with Heart Failure [ATMOSPHERE], NCT00853658; Prospective Comparison of ARNI [Angiotensin Receptor-Neprilysin Inhibitor] with ACEI [Angiotensin-Converting-Enzyme Inhibitor] to Determine Impact on Global Mortality and Morbidity in Heart Failure Trial [PARADIGM-HF], NCT01035255; Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure [GALACTIC-HF], NCT02929329)

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Journal of the American College of Cardiology

Título del artículo:

Radial Domichnia–Fodinichnia ichnofossil from the Lower Cretaceous of San Andrés (Santander, Colombia)

Introduction. Burrow and tunnel systems preserved in sandy and muddy marine substrates are commonly associated with the behavioral activities of polychaete worms and other benthic invertebrates, providing relevant ethological information in sedimentary records. Objectives. This study aims to i) describe the morphological and ethological characteristics of a radial ichnofossil, ii) evaluate its possible correspondence with previously established radial ichnogenera, and iii) propose paleoecological interpretations of the trace-making organism and its depositional environment. Materials and Methods. A detached sandstone block from the Aguardiente Formation (Albian–Cenomanian, Lower Cretaceous) was examined along the banks of the Hisgaura River, San Andrés municipality (Santander, Colombia). The trace architecture was documented through high-resolution photography, digital image processing, and artificial intelligence–assisted three-dimensional reconstruction to enhance visualization of its morphology and internal organization. UPGMA–Jaccard similarity and parsimony analyses were applied to assess relationships with other radial and rosette ichnogenera. Results. The specimen is preserved in full relief and consists of a central ellipsoidal chamber from which slightly sinuous tubular galleries radiate, locally arranged in superposed tiers. Similarity analysis groups the structure with Arenituba, Guanshanichnus, and Hartsellea. Parsimony analysis recovered a single most-parsimonious tree (length = 32 steps; CI = 0.34; RI = 0.7) in which the specimen forms part of a clade characterized primarily by branched galleries and shallow-marine occurrence. Conclusions. The structure records ethological evidence of a benthic organism inhabiting sandy shallow-marine environments. Diagnostic differences preclude confident assignment to any previously established radial ichnogenus.

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Innovaciencia

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Cardioneuroablation versus cardiac pacemaker in the management of dominant cardioinhibitory vasovagal syncope: a retrospective cohort study

Background: Refractory dominant cardioinhibitory vasovagal syncope (VVS) remains a therapeutic challenge in patients older than 40 years. Dual-chamber pacemakers with closed-loop stimulation (CLS-PM) are guideline-supported, while cardioneuroablation (CNA), targeting ganglionated plexus, has emerged as a device-free alternative. Direct comparative data between these strategies are limited. Methods: We conducted a retrospective, comparative cohort study including patients > 40 years with refractory cardioinhibitory VVS treated between 2018 and 2024. Patients underwent either CNA with extracardiac vagal stimulation validation (CNA-ECVS) or CLS-PM implantation. The primary outcome was recurrence of the first syncope episode. Secondary outcomes included syncope-free survival, syncope burden (≥ 50% reduction), and safety. Kaplan–Meier analysis and Cox proportional hazards models were applied. Results: Eighty patients were included (37 CNA-ECVS, 43 CLS-PM; mean age 58.0 ± 14.6 years). Patients in the CNA group were younger than those in the CLS-PM group (49.9 ± 10.3 vs. 65.0 ± 14.1 years; p < 0.001). During a mean follow-up of 3.8 years, syncope-free rates were 89.2% in the CNA group and 79.1% in the CLS-PM group (p = 0.363). Syncope-free survival did not differ significantly (log-rank p = 0.168), and recurrence risk was similar between strategies (HR 0.45; 95% CI 0.14–1.46; p = 0.182). Post-procedural syncope burden was numerically lower after CNA (10.8% vs. 20.9%) but without statistical significance. No major adverse events were observed in either group. Conclusions: In patients older than 40 years with refractory cardioinhibitory NCS, CNA with physiological validation and CLS-PM therapy demonstrated comparable efficacy and safety. Both strategies represent viable therapeutic options, warranting confirmation in randomized clinical trials.

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Journal of Interventional Cardiac Electrophysiology

Título del artículo:

Characterization of resistance in vitro to different antimicrobial in strains of Staphylococcus spp. in a hospital of the city of Valledupar between January and July 2009

The Staphylococcus spp. they can cause a wide range of infections systemic and located in community and hospital patients. Its high pathogenicity and growing resistance to multiple antimicrobials including methicillin, causes high morbiditymortality rates, causing a high epidemiological impact. Objective: to determine the phenotypic profile of resistance to different antimicrobials in strains of the genus Staphylococcus spp. Materials and methods: collected 75 strains and determined them susceptibility to different antibiotics by the Kirby-Bauer method. The production of betalactamase check using the nitrocefin test. (Resistance to Methicillin in S. aureus was conducted using Mueller Hinton with 4% NaCl and oxacillin 6 μg/mL). Inducible clindamycin resistance tamizo by D-Test test. Results: they were isolated by 38% of staphylococcus coagulase negative (SNA) and 62% of S. aureus. 53% were penicillin resistant staphylococci: S. aureus with 58% and 42% SNA. 47% of the strains showed resistance to methicillin: S. aureus with 61% and SNA with 39%. A strain of S. aureus showed inducible resistance to clindamycin (1.33%). Coagulase negative staphylococci were isolated mostly from blood samples (31%), blood (29%), tip of catheter (5%) and came mostly from neonatal ICU (25%), medical (21%) and surgery (16%). Conclusions: S. aureus and SNA were isolated with greater frequency in blood and wounds from surgery and neonatal ICU. The predominant resistance phenotypes were penicillin and oxacillin.

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Revista Ciencias de la Salud

Título del artículo:

Un reto para colombia: Mejorar la utilización de medicamentos probadamente beneficiosos en la prevención secundaria cardiovascular

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Colombia Medica

Título del artículo:

CD99 is expressed in chordoid glioma and suggests ependymal origin

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Virchows Archiv

Título del artículo:

Two-Dimensional free convection flow simulations on a square cavity through the use of lattice Boltzmann equation method

Convection is a key phenomenon found in different atmospheric and industrial applications. This work presents the numerical simulation of flow in a cavity which has been heated on one wall, in laminar regime, with Rayleigh numbers (Ra) of 103 ≤ Ra ≤ 106 and a Prandtl number of Pr = 0.7, through the lattice Boltzmann equation method -LBE. This technique has proven to be very efficient and powerful in computational fluid dynamics -CFD- (Y. W. Know, 2006). The flow velocity is calculated based on the use of density distribution function in the model D2Q9 -, with two dimensions and nine velocities. Temperature readings are obtained through the model D2T5 -, with two dimensions and five temperatures. The new thermal model used showed to be stable, and the results are highly accurate compared to the experimental and numerical results obtained through other CFD methods.

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Ingenieria y Universidad

Título del artículo:

Recurrent sycope secundary to primary cardiac rhabdomyosarcoma

Primary or secondary neoplasms can affect the heart. Secondary are more common. However, primary neoplasms are relevant because is a group with diverse genesis, behavior, treatment and clinical manifestations. We present a case of a 45 year-old woman, with recurrent syncope started 1 year before her first consult. She had palpitations and chest pain. Echocardiography identified a left atrium mass of 2.1 x 1.8 cm. Endomyocardial biopsy document a primary rhabdomyosarcoma of the heart. The patient dies after a overall-survival of 22 months. This case presented had a good study of its symptoms with an accurate diagnosis and early treatment, which provided prolonged survival of this rare and aggressive neoplasm.

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Archivos de Cardiologia de Mexico

Título del artículo:

Intrathyroidal parathyroid carcinoma in a pediatric patient

Parathyroid carcinoma is unusual and its intrathyroidal variant is extremely rare. Therefore, few cases have been reported to describe a case of parathyroid carcinoma located inside the thyroid gland. The case corresponds to a 14-year-old girl who came to the office with a severe osteoarticular disease, depression, calcemia of 14.3 mg/dl and parathyroid hormone of 2,792 pg/ml. Right neck exploration was conducted and a parathyroid carcinoma was found located intrathyroidally. A right thyroid lobectomy was performed. A 20-month follow-up period revealed no recurrence of clinical or biochemical signs. In patients with severe hypercalcemia and significant elevation of parathyroid hormone, the diagnosis of parathyroid carcinoma has to be considered. It is worth highlighting the early age of presentation in this case. Treatment has allowed the effective control of the disease and its recommended long-term follow-up. © 2011 Springer-Verlag.

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Pediatric Surgery International

Título del artículo:

Ontogeny of strobili, sporangia development and sporogenesis in Equisetum giganteum (Equisetaceae) from the Colombian Andes

Studies on the ontogeny of the strobilus, sporangium and reproductive biology of this group of ferns are scarce. Here we describe the ontogeny of the strobilus and sporangia, and the process of sporogenesis using specimens of E. giganteum from Colombia collected along the Rio Frio, Distrito de Sevilla, Piedecuesta, Santander, at 2 200m altitude. The strobili in different stages of development were fixed, dehydrated, embedded in paraffin, sectioned using a rotatory microtome and stained with the safraninO and fast green technique. Observations were made using differential interference contrast microscopy (DIC) or Nomarski microscopy, an optical microscopy illumination technique that enhances the contrast in unstained, transparent. Strobili arise and begin to develop in the apical meristems of the main axis and lateral branches, with no significant differences in the ontogeny of strobili of one or other axis. Successive processes of cell division and differentiation lead to the growth of the strobilus and the formation of sporangiophores. These are formed by the scutellum, the manubrium or pedicel-like, basal part of the sporangiophore, and initial cells of sporangium, which differentiate to form the sporangium wall, the sporocytes and the tapetum. There is not formation of a characteristic arquesporium, as sporocytes quickly undergo meiosis originating tetrads of spores. The tapetum retains its histological integrity, but subsequently the cell walls break down and form a plasmodium that invades the sporangial cavity, partially surrounding the tetrads, and then the spores. Towards the end of the sporogenesis the tapetum disintegrates leaving spores with elaters free within the sporangial cavity. Two layers finally form the sporangium wall: the sporangium wall itself, with thickened, lignified cell walls and an underlying pyknotic layer. The mature spores are chlorofilous, morphologically similar and have exospore, a thin perispore and two elaters. This study of the ontogeny of the spore-producing structures and spores is the first contribution of this type for a tropical species of the genus. Fluorescence microscopy indicates that elaters and the wall of the sporangium are autofluorescent, while other structures induced fluorescence emitted by the fluorescent dye safranin O. The results were also discussed in relation to what is known so far for other species of Equisetum, suggesting that ontogenetic processes and structure of characters sporoderm are relatively constant in Equisetum, which implies important diagnostic value in the taxonomy of the group.

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Revista de Biologia Tropical

Título del artículo:

Criterion validity of AUDIT for alcohol dependence screening in primary health care patients

Objective: To determine the validity of AUDIT criteria for the detection of alcohol dependence in adult patients of primary care in Bucaramanga, Colombia. Methods: An analytical study of the criterion validity of a scale was conducted following the recommendations of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). A total of 243 adult users of primary healthcare services, aged between 18 and 65 years, were included. Data were collected between April 4 and November 10, 2018. A Colombian version of AUDIT was applied. Subsequently, trained personnel conducted The Mini-International Neuropsychiatric Interview anonymously. Results: The area under the curve is 0.87. The optimal cut-off point for the AUDIT, according to the value obtained in the highest Youden index, 0.69, was ≥ 3 points and showed the following indicators: sensitivity 0.84 (95%CI: 0.80-0.89), specificity 0.84 (95%CI: 0.790.88), negative predictive value 0.99 (95%CI: 0.97-1); positive predictive value 0.22 (95%CI: 0.17-0.27). Conclusions: The AUDIT proved to be valid and reliable in identifying possible cases of alcohol dependence in primary care users with a cut-off point ≥ 3. These findings are significant for public health, as they support the early detection of a high-burden disorder and inform the development of timely intervention strategies in Colombia.

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Revista Facultad Nacional De Salud Publica