Herramientas de Accesibilidad
Society is constantly changing, therefore, it must be reinvented based on these, implying the search for new ways of seeing reality, for this, it is taken into account that in the Colombian context, education is focused on the results of learning, which account for specific skills, taking this into account, the general objective was raised: Analyze educational management for classroom management based on formative evaluation to obtain learning results, thus implying processes that they propitiate a higher educational quality for the achievement of what is expected of the student. To achieve this, documentary research was carried out through a qualitative research approach, with which 37 documents indexed in Scopus or Publindex databases were analyzed. These were arranged in an analysis matrix, where the discourse analysis technique was applied, and it was possible to find a set of emerging elements that allowed responding to the stated objective. Through this, it was concluded that the learning outcomes are positively impacted with the application of formative evaluation and adequate management in the classrooms, in this way, knowledge was transformed, and knowledge was complemented through management educational.
Aibi, Revista de Investigacion Administracion e Ingenierias
In Colombia, sacha inchi (Plukenetia volubilis, L) is planted as an alternative to coca cultivation. The plant adapts to diverse ecosystems, but research on its performance in different altitudinal gradients is scarce. The objective of the research was to analyze the relationship between altitude (0 to 1,800 meters above sea level) and seed weight, oil and cake yield of Catio 2-15 genetic material from 30 farms (60 observations) in the department of Norte de Santander (Colombia). The dry seeds were weighed, shelled, and the oil and cake were extracted. Data analysis was performed using descriptive and inferential estimators of Tukey\'s test, ANOVA and simple regression. The results indicate that there is a positive and highly significant relationship between altitude and seed weight, with the highest values between 600-1,800 meters above sea level, and a positive and non-significant relationship between altitude and sacha inchi oil and cake yield. The highest values for oil yield were found in the range 1,200-1,500 m.a.s.l and for cake yield between 900-1,800 m.a.s.l.
Aibi, Revista de Investigacion Administracion e Ingenierias
Pyometra is a bacterial infection with an accumulation of purulent exudate within the uterine lumen in intact female dogs. The diagnosis of this disease is made from the history, clinical and gynecological examinations, blood analyses, and ultrasonography of the abdomen. In this report, the clinical-surgical management of three cases of closed cervix pyometra is described. Three intact adult female dogs were presented to the veterinary emergency service because of general malaise, lack of appetite, and vomiting. The bitches showed estrus at least 3 weeks before the consultation, without vaginal discharge during this time. On clinical examination, the patients showed dehydration and apathy. Hematology, blood chemistry, and ultrasound were performed to confirm pyometra. Medical history, clinical, hematologic and chemistry findings, and abdominal ultrasonography were all consistent with a diagnosis of closed cervix canine Pyometra. Determinations of C-reactive protein were important to know the severity of inflammatory response before and post-surgery. Moreover, intraabdominal use of physiologic saline solution plus metronidazole and amoxicillin prevents secondary infections and decreases the inflammatory response. It concludes that the present report describes clinical and surgical management of closed cervix pyometra for optimizing monitoring, treatments, and saving the lives of patients with this disease.
International Journal of Veterinary Science
Background and Aim: To develop species-specific probiotics for poultry, it is ideal to obtain these probiotic microorganisms directly from the intestinal tract of broiler and egg-laying chicks in production environments to ensure adaptation to actual conditions. This study aimed to isolate lactic acid bacteria (LAB) from the intestinal tract of broiler and egg-laying chicks to determine their probiotic potential. Materials and Methods: Twenty-five Ross-308 broilers and 25 Isa Brown egg-laying chicks were raised until days 42 and 120, respectively; they were housed in an individual poultry building. Lactic acid bacteria were isolated and identified from the small intestine mucus of broiler and layer chicks and then evaluated based on resistance to acidic pH levels, bile salt concentration, and antagonistic activity against wild strains of Escherichia coli and Salmonella spp. selected strains with probiotic potential were identified by polymerase chain reaction and confirmed by rDNA sequencing. Results: One hundred and fifty Gram-positive isolates were obtained; 28% (42) were catalase and oxidase negative and biochemical identification was made by crystal system: 76.2% (32) Enterococcus spp., 16.6% (7) Lactococcus spp., and 7.2% (3) Streptococcus spp.; and evaluated for hemolysin production; tolerance to low pH and bile salts, and antagonistic potential were carried out. Molecular characterization yielded 56% (24) Enterococcus faecium, and 44% (18) Enterococcus faecalis. About 81% (34) of strains were without vancomycin resistance genes criterion. Conclusion: This study isolated and characterized 36 strains of LAB with probiotic qualities, from the intestines of broiler and egg-laying chicks, selecting E. faecium, Enterococcus avium, and Enterococcus casseliflavus, Lactococcus garviae as promising strains for further in vitro and in vivo research.
Veterinary World
The objective of this paper is to evaluate and assess the potential of green hydrogen (H2) as a substitute fuel for Cameroon\'s road transportation system. To achieve this objective, we start by providing a status quo of Cameroon\'s road transport. Then, we conduct an empirical analysis on the potential of H2 as a fuel for vehicles. Based on photovoltaic electrolysis, we estimate the amount of H2 needed to fuel vehicles with the associated costs as well as the quantity of carbon emissions that could be reduced in the event of an energy switch over the period 2020–2035. Finally, techno-economic indicators are used to assess the cost-effectiveness of an H2 vehicle in comparison to a petrol car. Results reveal that if a transition were to take place before 2035 the Cameroonian road transport sector would need between 1.75 MT and 2.5 MT of H2 fuel per year. With this transition, Cameroon could reduce its emissions by around 26% (or 429 megatons of CO2 equivalent). Hydrogen-fuelled vehicles offer the greatest potential for initiating this transition with the current level of technology. Indeed, starting from an investment cost for PV of 0.42 USD/Wp, H2 in a hydrogen-fuelled vehicle can be cost-effective compared with petrol in an internal combustion engine with a PV efficiency of 40%. Therefore, a hydrogen fuel-based transport sector could emerge through technological and production advances. This study contributes to solving the problems related to fossil fuel availability and greenhouse gas emissions arising from the expansion of the road transport sector in Cameroon, envisaging H2 as an alternative fuel.
International Journal of Hydrogen Energy
Type 2 diabetes mellitus (T2DM) is a highly prevalent disease, which has shown a rapid increase in recent decades, doubling the number of people with this disease. Several epidemiological studies show that 70% of diabetes deaths are caused by cardiovascular events (coronary heart disease and stroke). Recently there has been an expansion in the discovery of drugs for the management of type 2 diabetes. These drugs must demonstrate additional cardiovascular system benefi ts before its introduction in the market. This paper aims to determine the role of new antidiabetic drugs that act on the incretin system and its effects on the primary prevention of cardiovascular events.
Revista Colombiana de Cardiologia
Background: The anaplastic ganglioglioma (AG) is the high-grade counterpart of ganglioglioma, a rare mixed tumor composed of neuronal/ganglion and glial cells. Materials and methods: We describe the histopathology and immunohistochemistry in 7 cases of AG and correlate them with the clinical and radiological features. Results: Our AG patients correspond to 2.5% of the central nervous system tumor patients evaluated in our institution. The mean age at presentation was 25.7 years, with a male predominance. The most common clinical presentation was generalized tonic-clonic seizures (3/7 cases), in correlation with frequent cortical/subcortical location (6/7 cases). Histopathologically, all our cases showed high-grade features in glial (glial fibrillary acid protein-positive) and neuron-ganglion cells (synaptophysin, PGP-9.5, neurofilament, NSE and CD56-positive), as well as moderate cellularity, frequent mitotic figures and a Ki-67 labeling index >5%. All our patients had poor survival. Conclusion: We found that a typical histopathological and immunohistochemical profile is constant and can be useful in early diagnosis of these aggressive neoplasms. © 2013 Sociedad Española de Neurocirugía.
Neurocirugia
Despite intense research efforts, no approved effective therapies are available for dengue treatment. Standardized plant extracts could serve as potential candidates for developing plant-based treatments for dengue. We have compared the anti-dengue potential of ethanolic (EtOH) and supercritical (SCO2) extracts of Lippia origanoides Kunth (Verbenacea). The mode of antiviral action and the effect on the release of IL-β from DENV-1-stimulated macrophages (PMA/THP-1) were evaluated. In silico analyses were performed to predict molecular interactions between flavonoids identified in the UHPLC–ESI+–Orbitrap–MS analysis and target proteins. The EtOH extract showed a strong antiviral effect (IC50, 22 and 17 µg/mL; SI, 20 and 23) before and during DENV-1 adsorption to liver (HepG-2) cells. SCO2 showed a weak antiviral effect. EtOH, but not SCO2, reduced the level of IL-1β released from PMA/THP-1 cells by 45-55%. Flavonoid glycosides were identified in EtOH but not in SCO2. Seventeen flavonoids were predicted to bind to DENV E, GRP78, CLEC5A, and NLRP3 proteins involved in DENV replication and IL-1β production. The data provide a first step towards defining the potential of L. origanoides extract as a candidate for developing phytotherapeutics for dengue.
Records of Natural Products
Background: Higher medication adherence reduces the risk of new cardiovascular events. However, there are individual and health system barriers that lead to lower adherence. The polypill has demonstrated benefits in cardiovascular morbidity and mortality mainly driven by an increase in adherence. We aim to evaluate the impact of the polypill on adherence to cardiovascular medication, its efficacy and safety in cardiovascular disease (CVD) prevention. Methods: A systematic review following PRISMA guidelines was conducted. Databases were searched from January 2003 to December 2022. We included randomized, pragmatic, or real-world clinical trials and observational studies. The primary outcome was medication adherence, secondary outcomes were efficacy in cardiovascular disease in primary and secondary prevention and safety. Results: From the 490 publications screened, 13 met the inclusion criteria and were incorporated into a comparative table Of those included, 70% were randomized controlled trials (RCTs) and 53.8% focused on secondary prevention. Most of the studies received a high and moderate quality rating. Self-report, pill counting and, the Morisky scale were the most frequent methods to evaluate adherence (84.6%). Compared with standard medication, the polypill improved overall medication adherence by 13%, with percentages ranging from 7.6% to 34.9%. Moreover, a potential benefit was also observed in reducing Major Adverse Cardiovascular Events (MACE), particularly in secondary prevention studies, with hazard ratios ranged between 0.43 to 0.76. Compared to standard care, the profile of side effects was similar. Conclusion: The polypill is an effective, safe, and practical strategy to improve adherence in people at risk of CVD. Although there is a demonstrated benefit in reducing MACE, predominantly in secondary prevention, there are still gaps in its efficacy in primary prevention and reducing total mortality. Therefore, the importance of obtaining long-term results of the polypill effect and how this strategy can be implemented in real practice.
Vascular health and risk management
The Duffy protein, a transmembrane molecule, acts as a receptor for various chemokines and facilitates binding between reticulocytes and the Plasmodium Duffy antigen binding protein. Duffy expression is associated with the Duffy chemokine receptor antigen genotype on chromosome 1 and exhibits variation across different geographic regions. Traditionally, the Duffy negative genotype and phenotype have been described to confer a certain level of protection against infection and symptom development. However, recent data suggest a shift in this behavior, with significantly high-er prevalence observed in individuals with Duffy negative genotype or phenotype. Given that malaria is an endemic vector-borne disease in regions of Asia, Afri-ca, and Latin America, posing a substantial global bur-den of disease and prioritizing public and global health, identifying evolutionary changes in infection and resistance patterns holds great importance for the design of strategies and reevaluation of conventional interventions. Hence, the aim of this review was to analyze the evolution of Plasmodium vivax and infection resistance patterns based on Duffy genotype and phenotype. The distribution of genotypes, phenotypes, and polymorphisms of P. vivax ligands and erythrocyte receptors varies geographically, notably resistance patterns of this microorganism in individuals with Duffy negative genotype and phenotype have significantly changed compared to studies conducted 30 years ago. The prevalence of vivax malaria in individuals with a Duffy negative status can reach up to 100%. Conse-quently, prioritizing research on this topic is essential for public health.
Infezioni in Medicina
Objective. To identify DNA methylation patterns of heavy smokers in oral rinse samples. Methods. Genome-wide DNA methylation data was imported from Gene Expression Omnibus GSE70977 using the GEOquery package. Two independent sets were analyzed: (a) 71 epigenomes of cancer-free subjects (heavy smokers n = 37 vs. non-smokers n = 31); for concordance assessment (b) 139 oral-cancer patients’ epigenomes (heavy smokers n = 92 vs. non-smokers n = 47). Differential DNA methylation for CpG positions and at the regional level was determined using Limma and DMRcate Bioconductor packages. The linear model included sex, age, and alcohol consumption. The statistical threshold was set to p < 0.05. Functional gene prioritization analysis was performed for gene-targeted analysis. Results. In individuals without cancer and heavy smokers, the FAM184B gene was found with two CpG positions differentially hypermethylated (p = 0.012 after FDR adjustment), in a region of 48 bp with an absolute methylation difference >10% between groups (p = 1.76 × 10−8). In the analysis corresponding to oral-cancer patients, we found AHRR differentially hypomethylated cancer patients, but also in subjects without oral cancer in the targeted analyses. Remarkably, ADAMTS2 was found differentially hypermethylated in heavy smokers without a diagnosis of cancer in two consecutive probes cg05575921 (p = 3.13 × 10−7) and cg10208897 (p = 1.36 × 10−5). Conclusions: Differentially methylated AHRR, ADAMTS2, and FAM184B genes are biomarker candidates in oral rinse samples.
Biomedicines
Psyllids (Hemiptera: Psylloidea) can transmit the phloem restricted bacterium ‘Candidatus Liberibacter solanacearum’ (Lso). In Europe, Lso causes severe losses to carrot and represents a threat to the potato industry. A rising concern is Lso transmission from carrot to potato and within potato, and this has driven the need for monitoring populations of psyllid species which could serve as vectors on both crops. This would provide a fundamental understanding of the epidemiology of Lso. Different sampling methods were used to survey populations of psyllid species in commercial carrot and potato fields in central and eastern mainland Spain from 2015 to 2017. Two psyllid species, Bactericera trigonica and Bactericera nigricornis were found on carrot and potato crops. In carrot fields the most abundant species was B. trigonica (occurring from crop emergence to harvest); whereas in potato crops the most abundant psyllid species was B. nigricornis. Depending on field location, the maximum psyllid populations occurred between June and October. Since B. nigricornis was found on both carrot and potato and is the only psyllid species able to feed and reproduce on both these crops in Europe, there is the potential risk of Lso transmission from carrot to potato.
Insects
Revista Colombiana de Cardiologia
Background: Metabolic syndrome (MetS) is a disorder associated with an increased risk for the development of diabetes mellitus and its complications. Lower isometric handgrip strength (HGS) is associated with an increased risk of cardiometabolic diseases. However, the association between HGS and arterial stiffness parameters, which are considered the predictors of morbidity and mortality in individuals with MetS, is not well defined. Objective: To determine the association between HGS and HGS asymmetry on components of vascular function in adults with MetS. Methods: We measured handgrip strength normalized to bodyweight (HGS/kg), HGS asymmetry, body composition, blood glucose, lipid profile, blood pressure, pulse wave velocity (PWV), reflection coefficient (RC), augmentation index @75 bpm (AIx@75) and peripheral vascular resistance (PVR) in 55 adults with a diagnosis of MetS between 25 and 54 years old. Results: Mean age was 43.1 ± 7.0 years, 56.3% were females. HGS/kg was negatively correlated with AIx@75 (r = −0.440), p < 0.05, but these associations were not significant after adjusting for age and sex. However, when interaction effects between sex, HGS/kg and age were examined, we observed an inverse relationship between HGS/kg and AIx@75 in the older adults in the sample, whereas in the younger adults, a weak direct association was found. We also found a significant association between HGS asymmetry and PVR (beta = 30, 95% CI = 7.02; 54.2; p <0.012). Conclusions: Our findings suggest that in people with MetS, maintaining muscle strength may have an increasingly important role in older age in the attenuation of age-related increases in AIx@75—a marker of vascular stiffness—and that a higher HGS asymmetry could be associated with a greater vascular resistance.
Biomedicines
Introduction: We know of no studies on the microsporogenesis of the cocoa plant, and little is known about the ultrastructure of its pollen grains. Objective: To describe microsporogenesis and ultrastructure of pollen grains in T. cacao. Methods: We processed over 30 flowers for each floral stage and stained with Safranin-Alcian Blue, PASAmidoblack and Lacmoid. For transmission microscopy we processed samples on resin and stained with toluidine blue. For scanning electron microscopy, we fixed and dehydrated in 2.2-dimethoxypropane, critically dried and coated with gold. Results: Anthers differentiated by a cellular mass at the ends distal to the staminal filaments. During development, the anther wall has several cellular layers reduced, at maturity, to the epidermis and endothecium. Microspore mother cells divide by meiosis to form tetrads. The tapetum is secretory and intact until the grains are released, to later degenerate. Pollen grains are isopolar, spheroidal, small, tricolpate. Ultrastructure has a semi-tectate sporodermis, with reticulate ornamentation, and heterobrochated reticulum with the muri without ornamentation. Exine is deposited before intine. The orbicles are individual, smooth, and varied in size. There is abundant pollenkitt on the tectum and between the columellae. The intine is thin, but develops widely in the colpus areas, forming a compact internal intine and an unusual external intine with a columellated appearance. Conclusion: Anther structure and development follows the angiosperm pattern. Simultaneous microsporogenesis and centripetal deposition of the sporodermis are known from Malvaceae, but intine characters are novel for the family.
Revista de Biologia Tropical
Background: The psychological impact of the COVID-19 pandemic on healthcare professionals has been widely studied, along with different strategies to minimize it. However, professionals’ assessment of the social support received and the factors that mitigated their fear of contagion have not been described. This study aimed to assess healthcare professionals’ satisfaction with the social support and information received and their efforts to self-isolate to avoid infecting loved ones in Chile, Colombia, and Ecuador. Methods: A cross-sectional online survey, conducted from July to September 2020 in three Latin American countries, elicited healthcare professionals’ satisfaction with social support from colleagues, their community, the media, and scientific societies; as well as the information received about the evolution of the pandemic and measures to avoid contagion. The EASE scale was used to measure acute stress. Results: Survey responses were received from 700 professionals. The response rate per country exceeded the estimated sample size except in the case of Colombia, which was 81.4%. In general, peer support was highly valued, though satisfaction was lower in high-risk units (p < 0.001). Those who directly assisted COVID-19 patients perceived the least community support (p = 0.023). Professionals from high-risk units (p = 0.013) and those who experienced greater acute stress (p = 0.05) assigned the lowest rating to the information offered by the centre on the pandemic. Men perceived more support from colleagues and better information from the centre than women (p < 0.05). Just 10.7% of professionals changed their residence during the pandemic, but those who worked in high-risk areas self-isolated more frequently (p = 0.026). Conclusion: In the early stages of the COVID-19 pandemic, healthcare professionals in Chile, Colombia, and Ecuador greatly valued the support received from their peers. Being infected with COVID-19, working in high-risk areas, experiencing higher self-reported acute stress, and having an infected co-worker were predictors for self-isolation to protect their relatives. These results point to the appropriateness of putting in place institutional resources based on peer support and specific communication strategies and action protocols to build resilience and responsiveness to future health crises.
Frontiers in Psychology
Background: Acute respiratory infections (ARI) in Cúcuta -Colombia, have a comparatively high burden of disease associated with high public health costs. However, little is known about the epidemiology of these diseases in the city and its distribution within suburban areas. This study addresses this gap by estimating and mapping the risk of ARI in Cúcuta and identifying the most relevant risk factors. Methods: A spatial epidemiological analysis was designed to investigate the association of sociodemographic and environmental risk factors with the rate of ambulatory consultations of ARI in urban sections of Cúcuta, 2018. The ARI rate was calculated using a method for spatial estimation of disease rates. A Bayesian spatial model was implemented using the Integrated Nested Laplace Approximation approach and the Besag-York-Mollié specification. The risk of ARI per urban section and the hotspots of higher risk were also estimated and mapped. Results: A higher risk of IRA was found in central, south, north and west areas of Cúcuta after adjusting for sociodemographic and environmental factors, and taking into consideration the spatial distribution of the city’s urban sections. An increase of one unit in the percentage of population younger than 15 years; the Index of Multidimensional Poverty and the rate of ARI in the migrant population was associated with a 1.08 (1.06—1.1); 1.04 (1.01—1.08) and 1.25 (1.22—1.27) increase of the ARI rate, respectively. Twenty-four urban sections were identified as hotspots of risk in central, south, north and west areas in Cucuta. Conclusion: Sociodemographic factors and their spatial patterns are determinants of acute respiratory infections in Cúcuta. Bayesian spatial hierarchical models can be used to estimate and map the risk of these infections in suburban areas of large cities in Colombia. The methods of this study can be used globally to identify suburban areas and or specific communities at risk to support the implementation of prevention strategies and decision-making in the public and private health sectors.
BMC Public Health
Candida tropicalis is one of the most pathogenic species within the genus. Increased antifungal resistance has been reported, which is in part due to the organism’s ability to form biofilms. In natural products derived from plants, such as essential oils (EOs) or their major components, there is significant potential to develop new antifungals or to both enhance the efficacy and reduce the toxicity of conventional antifungals. This study aimed to evaluate the effect of combining an EO of Lippia origanoides or thymol with fluconazole on an azole-resistant C. tropicalis strain. Synergism was observed in the combination of fluconazole with the EO and with thymol, and minimal inhibitory concentrations for fluconazole decreased at least 32-fold. As a consequence of the synergistic interactions, mitochondrial membrane potential was reduced, and mitochondrial superoxide production increased. Alteration in nuclear morphology, cell surface, and ultrastructure was also observed. In conclusion, the synergistic interaction between L. origanoides EO or thymol with fluconazole reverted the azole-resistant C. tropicalis phenotype. These findings suggest that L. origanoides EO or thymol alone, or in combination with fluconazole, have the potential for development as antifungal therapies for this yeast, including resistant strains.
Journal of Fungi
Morbidity statistics can be reported as grouped data for health services rather than for individual residence area, especially in low-middle income countries. Although such reports can support some evidence-based decisions, these are of limited use if the geographical distribution of morbidity cannot be identified. This study estimates the spatial rate of Acute respiratory infections (ARI) in census districts in Cúcuta -Colombia, using an analysis of the spatial distribution of health services providers. The spatial scope (geographical area of influence) of each health service was established from their spatial distribution and the population covered. Three levels of spatial aggregation were established considering the spatial scope of primary, intermediate and tertiary health services providers. The ARI cases per census district were then calculated and mapped using the distribution of cases per health services provider and the proportion of population per district in each level respectively. Hotspots of risk were identified using the Local Moran’s I statistic. There were 98 health services providers that attended 8994, 18,450 and 91,025 ARI cases in spatial levels 1, 2 and 3, respectively. Higher spatial rates of ARI were found in districts in central south; northwest and northeast; and southwest Cúcuta with hotspots of risk found in central and central south and west and northwest Cucuta. The method used allowed overcoming the limitations of health data lacking area of residence information to implementing epidemiological analyses to identify at risk communities. This methodology can be used in socioeconomic contexts where geographic identifiers are not attached to health statistics.
GeoJournal
The creole breed Blanco Orejinegro (Bos taurus adapted) is an important animal genetic resource in Colombia. However, very little is known about the reproductive physiology of the breed. The objective was to determine the dynamics of progesterone circulation and follicular growth in Blanco Orejinegro cows throughout the estrous cycle. Fifteen cyclic Blanco Orejinegro cows were used and subjected to hormonal protocol for estrous and ovulation synchronization. Once the time of ovulation was identified by monitoring the ovarian dynamics with ultrasonography equipment. For description of the results, the mean was used as a measure of central tendency and the standard error of the mean. Statistical analysis was longitudinal descriptive. Blood samples were collected every 24 hr throughout the estrous cycle for serum quantification of progesterone (P4), monitoring of corpus luteum (CL) growth dynamics and follicular dynamics. It was possible to verify that 76.92% of the Blanco Orejinegro cows presented two follicular waves during the estrous cycle and the highest circulating levels of P4 (> 6.00 ng mL-1) were observed on the 14th day of the estrous cycle. It was concluded that the creole cows of the Blanco Orejinegro breed presented two follicular waves per estrous cycle. In addition to, the size of the CL was consistent with the secretion of progesterone presenting higher circulating levels at the end of the luteal phase.
Veterinary Research Forum
Austrian syndrome corresponds to the triad of meningitis, pneumonia, and endocarditis caused by Streptococcus pneumoniae, there is no global or local incidence given the infrequency of entity. Scarce cases are published in Latin America, with none of them in Colombia. A case of Austrian syndrome by penicillin-resistant S. pneumoniae in an immunocompetent patient is presented. Aortic valve is the most frequent site involved in Austrian syndrome; this patient had an unusual localization of the vegetation on the right coronary artery ostium. The prognosis is poor with a mortality rate of 30% or higher, this patient survived despite systemic complications. Vaccination status impacts in prevention and severity of cases because responsible serotypes are often included in available vaccines. The patient had a serotype covered by available vaccines; however, her vaccination status was unknown. Thus, we present the first case reported in Colombia of Austrian syndrome by a penicillin-resistant S. pneumoniae, in a patient with no identified comorbidities or toxicological history, with a successful evolution.
Thoracic Research and Practice
Purpose: The aim of this study was to optimize the immunoresponsive and anti-Candida albicans (C. albicans) properties of guided bone regeneration-resorbable membranes (collagen) using additives based on synergistic mixtures of chlorhexidine with terpene-enriched fractions from Lippia alba essential oils (EO). Methods: The anti-C. albicans activity of the fractions (individually or combined with chlorhexidine) was evaluated using planktonic and sessile cultures. J774A.1 murine macrophage cells were used to determine the cytotoxicity and immunoresponsive effects of the therapies. Results: The anti-planktonic and anti-sessile performance of chlorhexidine on C. albicans was improved 2-to 4-fold by supplementation with citral-rich fractions. On macrophages, this fraction also exhibited a potentially cytoprotective action against the toxic effects of chlorhexidine, minimiz-ing damage to the cell membrane, mitochondrial membrane potential, and nuclear integrity. Macrophages growing on collagen-membrane frag-ments and stimulated with the citral fraction (alone or with chlorhexidine) showed a significant increase in releasing the osteogenic cytokine TNF-α and enhancing the IL-4. Conclusion: This combined therapy appears as a promising platform for the development of a prophylactic or therapeutic biocidal solution that can optimize the pharmacological characteristics of chlorhexidine (epithelium tolerance and anti-C. albicans consolidation on surfaces), as well as poten-tiating the immunoresponsive properties of collagen membranes.
Journal of Oral Science
This study aimed to determine the within- and between-session reliability of ankle mechanics and vertical ground reaction forces (vGRF) during jump landings in turned-out and parallel foot positions in professional ballet dancers. Twenty-four professional ballet dancers (men = 13, women = 11) attended two data collection sessions where they completed five maximal countermovement jumps in each foot position. The ankle joint mechanics and vGRF of the right limb were recorded via a seven-camera motion capture system and one force platform. Within- and between-session intraclass correlation coefficients (ICC), coefficients of variation (CV), standard error of measurement, and minimal detectable change were calculated for three-dimensional ankle excursion, peak ankle angle, ankle joint velocity, moment, and power, as well as peak landing vGRF, time to peak landing vGRF, loading rate, and jump height. Across both foot positions, within- (ICC: 0.17–0.96; CV: 1.4–82.3%) and between-session (ICC: 0.02–0.98; CV:1.3–57.1%) reliability ranged from poor to excellent, with ankle excursion, peak ankle angle, and jump height demonstrating the greatest ICC values (ICC: 0.65–0.96; CV: 1.4–57%). Jump landings in a turned-out foot position demonstrated better within-session reliability compared to a parallel position, however, no difference in between-session reliability across the foot positions was observed. Most ankle mechanics provide adequate between-session, but not within-session, reliability during jump landings in professional ballet dancers.
Journal of Biomechanics
This work studies the fermentation kinetics to produce mead using Saccharomyces cerevisiae, selected from three commercial yeasts to generate a product with better organoleptic characteristics and greater acceptance by a group of untrained tasters. The values of the kinetic parameters of the fermentation were obtained from a series of fermentations at laboratory scale, maintaining constant the initial concentration of biomass (1.5 g/L), the operating temperature (33 °C) and the pH (4) and varying the initial soluble solids concentration in four values (10, 16, 22 and 25 °Brix). Based on the experimental results, a mathematical modeling was developed to estimate the variables of interest. Thus, from the application of the Monod model, the saturation constant (Ks) of 336.6 g/L was obtained, with a maximum specific growth rate ((Formula presented.)) of 0.071 h−1. Using the integrated logistic model, the experimental values were adjusted to obtain the average value of (Formula presented.) of 0.0815 h−1. Finally, the maximum ethanol production rate (rpm) of 0.2621 g/L was obtained through the modified Gompertz model. Therefore, Monod, integrated logistic and modified Gompertz models were ideal mathematical tools to interpret the kinetic behavior of honey fermentations, predict and control this process, both on a laboratory scale and on a subsequent industrial scale. Thus, contributing to the knowledge of the dynamic behavior of mead production and its level of technological development.
Journal of the American Society of Brewing Chemists
This study explores the socio-political, economic and educational context in which the Instituto Colombiano de Crédito Educativo y Estudios Técnicos en el Exterior (Colombian Institute of Educational Credit and Technical Studies Abroad) was created. Studying the historical conditions allows us to answer the questions of why and how this institution arose in Colombia. Based on the Foucauldian assumptions on genealogy and the conditions of possibility, the study of this institution proposes its emergence to be an effect of several elements, which are approached critically. To this end, the article is divided into two sections wherein the idea of the creation of the Institute and the experiences it went through are analysed, to then deal with the materialisation of this idea in relation to the conditions of the Colombian environment.
Cogent Social Sciences
Universidad de Santander UDES. Vigilada Mineducación.
Resolución otorgada por el Ministerio de Educación Nacional: No. 6216 del 22 de diciembre de 2005 / Personería Jurídica 810 de 12/03/96.
Institución sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución 12220 de 2016.
Notificaciones administrativas y judiciales:
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