Título del artículo:

In silico approaches for polymeric nanocomposites

Polymer composites and nanocomposites have a wide range of applications in materials science and biomedicine, where both structural and functional requirements must be met. Conventional design approaches to synthesize and optimize these materials are mostly experimentally oriented. One step forward is to link experiments through a concrete design scheme to address key processes and validation of results. Recent advances in computational modeling and simulation driven by quantum computing and artificial intelligence have led to changes in the rational design of such versatile materials, enabling a deeper understanding of material formulation and behavior. Along the remarkable progress in computational materials engineering, the development of hybrid and multiscale approaches supported by machine learning algorithms is clearly a fruitful area of research. These approaches possess invaluable potential for exploring and predicting the behavior of polymer nanocomposites, discovering optimal materials and processes, and optimizing existing ones. This chapter aims to provide an overview of the computational approaches that support the experimental design of a variety of polymer nanocomposites and promote their performance evaluation in the pharmaceutical and biomedical fields. The focus is on the models, algorithms and methods proposed to facilitate the exploration of polymer nanocomposite design and synthesis and the prediction of soft material behavior. These will greatly expand the portfolio of in silico methods applied to these types of materials.

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In-Silico Approaches to Macromolecular Chemistry

Título del artículo:

Oocyte quality in adapted Bos taurus taurus cows

The objective of the current study was to determine the performance of creole cows of the Chino Santandereano breed in the ultrasound-guided follicular aspiration technique (OPU) and the quality of oocytes recovered. A total of 15 multiparous cows were selected from a herd located in the department of Santander with tropical climate. The cows were submitted to 5 sessions of follicular aspiration with an interval of 45 days. In each aspiration session, 7.9 ± 0.7 oocytes were recovered per cow, with a recovery rate of 64.9% ± 0.5 and a rate of viable and non-viable oocytes of 64.3% ± 0.6 and 35.7% ± 0.7, respectively. A difference (P < 0.05) in oocyte quality was presented for grades I, II and III (7.7 ± 0.4, 19.8 ± 0.5 and 36.8 ± 0.5, respectively). The results suggest that Chino Santandereano cows submitted to the OPU technique have a higher percentage of grade III oocytes recovered.

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Animal Biotechnology

Título del artículo:

Effect of FSH Stimulation with Pluronic® F127 on the Quality of Oocytes Collected by Follicular Aspiration in Bos taurus indicus Heifers

In bovine in vitro embryo production (IVP), FSH has been used to improve the quality and developmental capacity of oocytes to reach the blastocyst stage. The objective of this study was to evaluate in Bos taurus indicus heifers the effect of FSH incorporated in Pluronic® F127 on the quality of oocytes collected by follic-ular aspiration. A total of 30 cyclic Brahman heifers were selected and assigned into one of three experimental groups (control group, FSH-SC and FSH-PF127). Heifers in the FSH-SC group received a single dose of 50 mg FSH subcutaneously and heifers in the FSH-PF127 group were treated with 50 mg FSH incorporated in Pluronic® F127. The rate of viable oocytes was higher for the FSH-PF127 group compared to the control and FSH-SC groups. The administration of a single dose of 50 mg of FSH in Pluronic® F127 influenced the oocyte quality and the rate of viable oocytes of Brahman breed heifers.

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Journal of Advanced Veterinary Research

Título del artículo:

Medications for blood pressure, blood glucose, lipids, and anti-thrombotic medications: relationship with cardiovascular disease and death in adults from 21 high-, middle-, and low-income countries with an elevated body mass index

Aims Elevated body mass index (BMI) is an important cause of cardiovascular disease (CVD). The population-level impact of pharmacologic strategies to mitigate the risk of CVD conferred by the metabolic consequences of an elevated BMI is not well described. Methods We conducted an analysis of 145 986 participants (mean age 50 years, 58% women) from 21 high-, middle-, and low-in- and results come countries in the Prospective Urban and Rural Epidemiology study who had no history of cancer, ischaemic heart disease, heart failure, or stroke. We evaluated whether the hazards of CVD (myocardial infarction, stroke, heart failure, or cardiovascular death) differed among those taking a cardiovascular medication (n = 29 174; including blood pressure-lowering, blood glucose-lowering, cholesterol-lowering, or anti-thrombotic medications) vs. those not taking a cardiovascular medication (n = 116 812) during 10.2 years of follow-up. Cox proportional hazard models with the community as a shared frailty were constructed by adjusting age, sex, education, geographic region, physical activity, tobacco, and alcohol use. We observed 7928 (5.4%) CVD events and 9863 (6.8%) deaths. Cardiovascular medication use was associated with different hazards of CVD (interaction P, 0.0001) and death (interaction P = 0.0020) as compared with no cardiovascular medication use. Among those not taking a cardiovascular medication, as compared with those with BMI 20 to,25 kg/m2, the hazard ratio (HR) [95% confidence interval (95% CI)] for CVD were, respectively, 1.14 (1.06–1.23); 1.45 (1.30–1.61); and 1.53 (1.28–1.82) among those with BMI 25 to,30 kg/m2; 30 to,35 kg/m2; and ≥35 kg/m2. However, among those taking a cardiovascular medication, the HR (95% CI) for CVD were, respectively, 0.79 (0.72–0.87); 0.90 (0.79–1.01); and 1.14 (0.98–1.33). Among those not taking a cardiovascular medication, the respective HR (95% CI) for death were 0.93 (0.87–1.00); 1.03 (0.93–1.15); and 1.44 (1.24–1.67) among those with BMI 25 to,30 kg/m2; 30 to,35 kg/m2; and ≥35 kg/m2. However, among those taking a cardiovascular medication, the respective HR (95% CI) for death were 0.77 (0.69–0.84); 0.88 (0.78–0.99); and 1.12 (0.96–1.30). Blood pressure-lowering medications accounted for the largest population attributable benefit of cardiovascular medications. Conclusion To the extent that CVD risk among those with an elevated BMI is related to hypertension, diabetes, and an elevated thrombotic milieu, targeting these pathways pharmacologically may represent an important complementary means of reducing the CVD burden caused by an elevated BMI.

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European Journal of Preventive Cardiology

Título del artículo:

Biomechanical and Neuromuscular Performance Requirements of Horizontal Deceleration: A Review with Implications for Random Intermittent Multi-Directional Sports

Rapid horizontal accelerations and decelerations are crucial events enabling the changes of velocity and direction integral to sports involving random intermittent multi-directional movements. However, relative to horizontal acceleration, there have been considerably fewer scientific investigations into the biomechanical and neuromuscular demands of horizontal deceleration and the qualities underpinning horizontal deceleration performance. Accordingly, the aims of this review article are to: (1) conduct an evidence-based review of the biomechanical demands of horizontal deceleration and (2) identify biomechanical and neuromuscular performance determinants of horizontal deceleration, with the aim of outlining relevant performance implications for random intermittent multi-directional sports. We highlight that horizontal decelerations have a unique ground reaction force profile, characterised by high-impact peak forces and loading rates. The highest magnitude of these forces occurs during the early stance phase (< 50 ms) and is shown to be up to 2.7 times greater than those seen during the first steps of a maximal horizontal acceleration. As such, inability for either limb to tolerate these forces may result in a diminished ability to brake, subsequently reducing deceleration capacity, and increasing vulnerability to excessive forces that could heighten injury risk and severity of muscle damage. Two factors are highlighted as especially important for enhancing horizontal deceleration ability: (1) braking force control and (2) braking force attenuation. Whilst various eccentric strength qualities have been reported to be important for achieving these purposes, the potential importance of concentric, isometric and reactive strength, in addition to an enhanced technical ability to apply braking force is also highlighted. Last, the review provides recommended research directions to enhance future understanding of horizontal deceleration ability.

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Sports Medicine

Título del artículo:

\'Where is the load?\' Revisiting the Strategic Assessment of Risk and Risk Tolerance (StARRT) framework for return to sport by including an athlete\'s sport-specific training capacity?

The Strategic Assessment of Risk and Risk Tolerance (StARRT) framework has been instrumental in the way practitioners view return-to-sport (RTS) decision-making.1 2 According to the framework, RTS decisions should be based on the practitioner\'s risk assessment of outcome, involving an athlete\'s estimated risk compared with their risk tolerance within the particular context. Activity risk assessment is the second step in the StARRT framework, synthesising information relevant to the expected cumulative stresses placed on the injured tissue/structure(s). Several important factors are included in this assessment, but what is not listed is the athlete\'s sports-specific training capacity. This represents an athlete\'s overall ability to cope with diverse demands of training and competition imposed by their ecosystem and perform at the required level. It is perhaps the most ecologically important consideration since it encapsulates the \'actual\' demands and requirements of the athlete\'s sport and their level of participation.3-5 While the importance of monitoring training load in rehabilitation has been established,6 7 we emphasise that sufficient consideration has not been given to the role of the athlete\'s sports-specific training capacity in decision-making throughout the RTS continuum.5 8.

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British Journal of Sports Medicine

Título del artículo:

Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta-gamma coupling during recall

Hippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but not in the presence of a familiar one, triggers hippocampal theta-gamma coupling. Hippocampal theta-gamma coupling (hPAC) does not happen when ORM destabilization is prevented by blocking D1/D5 receptors, but artificial hPAC generation during recall in the presence of a familiar object enables the amnesic effect of reconsolidation inhibitors. Therefore, hPAC controls ORM destabilization, and its modulation could increase reconsolidation-based psychotherapy efficacy.

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Learning and Memory

Título del artículo:

A small step, a giant leap: Somatic hypermutation of a single amino acid leads to anti-la autoreactivity

The anti-La mab 312B, which was established by hybridoma technology from human-La transgenic mice after adoptive transfer of anti-human La T cells, immunoprecipitates both native eukaryotic human and murine La protein. Therefore, it represents a true anti-La autoantibody. During maturation, the anti-La mab 312B acquired somatic hypermutations (SHMs) which resulted in the replacement of four aa in the complementarity determining regions (CDR) and seven aa in the framework regions. The recombinant derivative of the anti-La mab 312B in which all the SHMs were corrected to the germline sequence failed to recognize the La antigen. We therefore wanted to learn which SHM(s) is (are) responsible for anti-La autoreactivity. Humanization of the 312B ab by grafting its CDR regions to a human Ig backbone confirms that the CDR sequences are mainly responsible for anti-La autoreactivity. Finally, we identified that a single amino acid replacement (D > Y) in the germline sequence of the CDR3 region of the heavy chain of the anti-La mab 312B is sufficient for anti-La autoreactivity.

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International Journal of Molecular Sciences

Título del artículo:

Associations of unprocessed and processed meat intake with mortality and cardiovascular disease in 21 countries [Prospective Urban Rural Epidemiology (PURE) Study]: a prospective cohort study

Background: Dietary guidelines recommend limiting red meat intake because it is a major source of medium- and long-chain SFAs and is presumed to increase the risk of cardiovascular disease (CVD). Evidence of an association between unprocessed red meat intake and CVD is inconsistent. Objective: The study aimed to assess the association of unprocessed red meat, poultry, and processed meat intake with mortality and major CVD. Methods: The Prospective Urban Rural Epidemiology (PURE) Study is a cohort of 134,297 individuals enrolled from 21 low-, middle-, and high-income countries. Food intake was recorded using country-specific validated FFQs. The primary outcomes were total mortality and major CVD. HRs were estimated using multivariable Cox frailty models with random intercepts. Results: In the PURE study, during 9.5 y of follow-up, we recorded 7789 deaths and 6976 CVD events. Higher unprocessed red meat intake (≥250 g/wk vs. <50 g/wk) was not significantly associated with total mortality (HR: 0.93; 95% CI: 0.85, 1.02; P-trend = 0.14) or major CVD (HR: 1.01; 95% CI: 0.92, 1.11; P-trend = 0.72). Similarly, no association was observed between poultry intake and health outcomes. Higher intake of processed meat (≥150 g/wk vs. 0 g/wk) was associated with higher risk of total mortality (HR: 1.51; 95% CI: 1.08, 2.10; P-trend = 0.009) and major CVD (HR: 1.46; 95% CI: 1.08, 1.98; P-trend = 0.004). Conclusions: In a large multinational prospective study, we did not find significant associations between unprocessed red meat and poultry intake and mortality or major CVD. Conversely, a higher intake of processed meat was associated with a higher risk of mortality and major CVD.

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American Journal of Clinical Nutrition

Título del artículo:

Post-COVID 19 Neurological Syndrome: A fresh challenge in neurological management

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Neurologia i Neurochirurgia Polska

Título del artículo:

Epidemiology of hypertension and diabetes mellitus in Latin America

Hypertension and type 2 diabetes mellitus are two important risk factors that contribute to cardiovascular diseases worldwide. In Latin America, hypertension prevalence varies from 30 to 50%. Moreover, the proportion of awareness, treatment and control of hypertension is very low. The prevalence of type 2 diabetes mellitus varies from 8 to 13% and around 40% of patients are un-aware of their condition. In addition, the prevalence of prediabetes varies from 6 to 14% and this condition has also been associated with increased risk of cardiovascular diseases. The principal factors linked to a higher risk of hypertension in Latin America are increased adiposity, low muscle strength, unhealthy diet, low physical activity and low education. Besides being chronic condi-tions, leading causes of cardiovascular mortality, both hypertension and type 2 diabetes mellitus, represent a substantial cost for the weak health systems of Latin American countries. Therefore, it is necessary to implement and reinforce public health programs to improve awareness, treatment and control of hypertension and type 2 diabetes mellitus, in order to reach the mandate of the United Nations to decrease the premature mortality for CVD.

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Current Hypertension Reviews

Título del artículo:

Comparison of the effects of aerobic and force exercise in patients with heart failure after a cardiovascular rehabilitation program: randomized controlled trial

Introduction and objectives: Cardiovascular diseases are the leading cause of mortality worldwide. Currently, rehabilitation programs are shown as adequate treatments to mitigate the effects of heart failure. The main objective is to compare the effects of aerobic exercise and strength in patients with heart failure after a cardiovascular rehabilitation program. Material and methods: Randomized controlled trial over a period of three years with a sample of 920 patients with heart failure distributed in two groups (aerobic exercise plus upper limb -MMSS- training and aerobic exercise plus training of lower limbs -MMII-). Blood samples were taken to determine blood glucose levels and lipid profile. In addition, tests for aerobic capacity, maximum heart rate, anthropometry, depression, anxiety, clinical and hemodynamic parameters. The tests were performed before and after 24 training sessions, 60 min, three times a week for two months. Results: Comparing the results between the groups, it was possible to show better results in the majority of the variables of group 2 (aerobic exercise + strength training MMII) (p ≤ 0.05%). However, no signifi cant post training diff erences were found in the HDL, LDL and triglyceride variables (p ≤ 0.05%). Conclusions: An aerobic training program combined with strength for patients with heart failure improves aerobic capacity, exercise tolerance, ejection fraction, glycemic indexes, MHR, muscle percentage and decreases body fat percentage and levels of depression and anxiety. These benefi ts stand out to a greater extent in an aerobic workout combined with MMII strength.

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Cardiovascular and Metabolic Science

Título del artículo:

Previous injury is associated with heightened countermovement jump force-time asymmetries in professional soccer players

Previous injury is associated with increased risk of future injury. Residual inter-limb deficits are a potential contributing factor leading to compensatory movement patterns on return to sport. The purpose of this study was to examine the effects of previous severe injury on bilateral ground reaction force asymmetries measured during a countermovement jump using a dual force platform. A total of 34 male professional soccer players (age 19 ± 2 years) were subdivided into two groups; previous severe injury (N = 17) or no severe injury (N = 17). Previously injured players showed significantly greater asymmetry in concentric phase variables (P < 0.05) with strong effect sizes (range = 0.99-1.35). These players also showed significantly elevated asymmetry in eccentric phase variables (P < 0.05) and medium to large effect sizes (range = 0.73-1.05), with the exception of eccentric deceleration impulse (P > 0.05; d = 0.33). There were no significant between-group differences in bilateral jump performance parameters (P > 0.05). These data indicate that despite being cleared to return to sport, participating in elite-level training, full competition and exhibiting no decrements in jump performance, significant inter-limb asymmetries persist in the concentric and eccentric phases of the CMJ.

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Translational Sports Medicine

Título del artículo:

Antifungal activity of Co(II) and Cu(II) complexes containing 1,3-bis(benzotriazol-1-yl)-propan-2-ol on the growth and virulence traits of fluconazole-resistant Candida species: synthesis, DFT calculations, and biological activity

Relevant virulence traits in Candida spp. are associated with dimorphic change and biofilm formation, which became an important target to reduce antifungal resistance. In this work, Co(II) complexes containing a benzotriazole derivative ligand showed a promising capacity of reducing these virulence traits. These complexes exhibited higher antifungal activities than the free ligands against all the Candida albicans and non-albicans strains tested, where compounds 2 and 4 showed minimum inhibitory concentration values between 15.62 and 125 μg mL−1. Moreover, four complexes (2–5) of Co(II) and Cu(II) with benzotriazole ligand were synthesized. These compounds were obtained as air-stable solids and characterized by melting point, thermogravimetric analysis, infrared, Raman and ultraviolet/visible spectroscopy. The analysis of the characterization data allowed us to identify that all the complexes had 1:1 (M:L) stoichiometries. Additionally, Density Functional Theory calculations were carried out for 2 and 3 to propose a probable geometry of both compounds. The conformer Da of 2 was the most stable conformer according to the Energy Decomposition Analysis; while the conformers of 3 have a fluxional behavior in this analysis that did not allow us to determine the most probable conformer. These results provide an important platform for the design of new compounds with antifungal activities and the capacity to attack other target of relevance to reduce antimicrobial resistance.

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BMC Chemistry

Título del artículo:

Sugar-sweetened beverage intakes among adults between 1990 and 2018 in 185 countries

Sugar-sweetened beverages (SSBs) are associated with cardiometabolic diseases and social inequities. For most nations, recent estimates and trends of intake are not available; nor variation by education or urbanicity. We investigated SSB intakes among adults between 1990 and 2018 in 185 countries, stratified subnationally by age, sex, education, and rural/urban residence, using data from the Global Dietary Database. In 2018, mean global SSB intake was 2.7 (8 oz = 248 grams) servings/week (95% UI 2.5-2.9) (range: 0.7 (0.5-1.1) in South Asia to 7.8 (7.1-8.6) in Latin America/Caribbean). Intakes were higher in male vs. female, younger vs. older, more vs. less educated, and urban vs. rural adults. Variations by education and urbanicity were largest in Sub-Saharan Africa. Between 1990 and 2018, SSB intakes increased by +0.37 (+0.29, +0.47), with the largest increase in Sub-Saharan Africa. These findings inform intervention, surveillance, and policy actions worldwide, highlighting the growing problem of SSBs for public health in Sub-Saharan Africa.

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Nature Communications

Título del artículo:

Metacognition as a factor of empowerment and development of learning skills in students.

The objective of this research article was to analyze the essential characteristics of metacognition in the teaching processes used as a didactic strategy for the development of learning skills in high school students and technical labor education of the Institute for Work and Human Development, Edunorte, Cucuta SAS. It was a mixed study, with field design and descriptive level. We worked with a population of 161 high school students and 25 teachers. The collection techniques were the survey for students and the interview for teachers. Regarding the questionnaire for students, a validated instrument was used, and for the interview, a script was designed and validated by expert judgment, based on the dimensions of reference authors. For the student questionnaire, a Cronbach\'s Alpha of 0.873 was calculated, very comparable with the validated original. The study was divided into two stages: the handling of the elements of metacognition in the learning processes by the students; and the incorporation of metacognition as a strategy for the development of competencies by teachers. In the results, it was found that, from the perspective of the students, there are quantitative results that show weaknesses in learning based on goals and objectives, personal learning planning, and repetition or change of strategy to improve learning. Teachers have a high determination of metacognitive processes, with the contribution of detecting weaknesses that can hinder student metacognition in their teaching processes, being challenges for the improvement of teaching and learning processes based on metacognition.

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Aibi, Revista de Investigacion Administracion e Ingenierias

Título del artículo:

Including Sustainability Criteria in the Front End of Innovation in Technology Ventures

This study evaluates the presence of sustainability parameters in the product development process, especially in the early stages of innovation, using the Sustainability Technology Readiness Level (STRL) tool. STRL assesses the initial planning of products or product and service systems (PSS) and suggests possibilities for incorporating sustainable features in the short, medium, and long term based on responses from startups (EBTs). The research was conducted in two ecosystems at different maturity levels: Florianópolis (Brazil), a more mature stage, and Santander (Colombia), which is growing, considering their cultural and social differences. To validate the STRL tool, four out of the eighteen winning startups from the MuEBTe SANTANDER public funding project in Colombia were selected. Characteristics of the two researched ecosystems, their actors, strengths, approaches, and expansion possibilities were identified and compared. The innovation lies in establishing a sustainable baseline when applying the tool by acquiring the front-end characteristic matrix. It was observed that sustainability as a variable has relevance and independence from product design in product planning, allowing for the selection of short, medium, and long-term actions throughout the product’s lifecycle. It was concluded that considering sustainability involves context and vision, resulting in significant choices of materials, processes, and production methods that add value and appreciation for the customer.

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Sustainability (Switzerland)

Título del artículo:

Graphic representations of health: a look from the children on the move in Medellín

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MedUNAB

Título del artículo:

A global action agenda for turning the tide on fatty liver disease

Background and Aims: Fatty liver disease is a major public health threat due to its very high prevalence and related morbidity and mortality. Focused and dedicated interventions are urgently needed to target disease prevention, treatment, and care. Approach and Results: We developed an aligned, prioritized action agenda for the global fatty liver disease community of practice. Following a Delphi methodology over 2 rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the action priorities using Qualtrics XM, indicating agreement using a 4-point Likert-scale and providing written feedback. Priorities were revised between rounds, and in R2, panelists also ranked the priorities within 6 domains: epidemiology, treatment and care, models of care, education and awareness, patient and community perspectives, and leadership and public health policy. The consensus fatty liver disease action agenda encompasses 29 priorities. In R2, the mean percentage of “agree” responses was 82.4%, with all individual priorities having at least a super-majority of agreement (> 66.7% “agree”). The highest-ranked action priorities included collaboration between liver specialists and primary care doctors on early diagnosis, action to address the needs of people living with multiple morbidities, and the incorporation of fatty liver disease into relevant non-communicable disease strategies and guidance. Conclusions: This consensus-driven multidisciplinary fatty liver disease action agenda developed by care providers, clinical researchers, and public health and policy experts provides a path to reduce fatty liver disease prevalence and improve health outcomes. To implement this agenda, concerted efforts will be needed at the global, regional, and national levels.

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Hepatology

Título del artículo:

The Benefits of Polypill: Adherence and Chronotherapy [Response to Letter]

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Vascular Health and Risk Management

Título del artículo:

Risk of eating disorders associated with the nutritional status of adolescents

Introduction: Eating disorders are described as complex disorders comprising two types of behavioral alterations: some directly related to food and weight and others derived from the relationship with oneself and others. Objective: To describe the risks of eating behaviors associated with the nutritional status of adolescents from public schools in Bucaramanga. Materials and methods: Observational, descriptive, cross-sectional study. The population corresponds to 471 adolescents between 10 and 19 years of age, from 19 educational institutions of the public network of Bucaramanga, multistage probabilistic sampling, the eating attitudes test (EAT26) was used, the perception of body image, comparisons were made according to sex and nutritional status with the X2 test. Results: Discussion and conclusions: Participants with eating behavior disorders have higher percentages in those with altered nutritional status (severe malnutrition, overweight and obesity) and differences were identified regarding body image according to nutritional status.

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Cultura de los Cuidados

Título del artículo:

Hospital waste management in a Service Provider Institution of the municipality of Los Patios, Norte de Santander, Colombia

Objective To analyze the process of integrated management of hospital and similar waste in a Service Provider Institution in the municipality of Los Patios, Norte de Santander. The established criteria in Decree 351 of 2014 and Resolution 1164 of 2002 were used. Method Mixed research was conducted using a combination of qualitative and quanti-tative paradigms. The study employed a field and bibliographic design at a descriptive level, involving a population of 90 officials assigned to the hospital entity. The data collection techniques utilized were interviews, surveys, and direct observation. Quan-titative data was processed using descriptive statistics, while qualitative information supported the triangulation of observations. Results First, the study revealed that 53.92% of the waste generated was classified as non-hazardous, while 46.08% was categorized as hazardous waste. Among the hazardous waste, a significant proportion of 96.60% was identified as infectious or biohazar-dous waste. Furthermore, the criteria considered for the management and disposal of hospital waste were described. Conclusions The health institution in the municipality of Los Patios has implemented an Integral Management Plan for Hospital and Similar Waste, which is currently in progress. However, there is a need to propose specific improvements to enhance its operations due to the identification of certain weaknesses. These weaknesses primarily pertain to the management of waste itself, as well as the lack of information among some staff members regarding the plan, its signi-ficance, and its proper management.

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Revista de Salud Publica

Título del artículo:

Desmoplastic infantile ganglioglioma with late presentation: A clinical, radiological and histopathological analysis

Desmoplastic infantile ganglioglioma (DIG) is a rare supratentorial tumor in the central nervous system. Definitive diagnosis of this neoplasm is based on histopathologic analysis evaluating distinctive findings such as the fibroblastic differentiation. Here we present a clinical case of DIG with a long follow-up in an eight-year-old boy with a six-month history of recurrent emesis, psychomotor hyperactivity and generalized tonic-clonic seizures. Computed tomography scan and magnetic resonance imaging (MRI) showed a cystic, heterogeneous, mass on the right temporal uncus. A histopathological diagnosis of late presentation DIG was made. We documented the immunohistochemical expression of a molecular soft tissue / muscle differentiation marker (h-CaD) in addition to a low proliferative index (Ki-67) in this case. After surgical intervention, a control MRI showed changes of right frontal-temporal craniotomy and a persistent mass in the anterior and medial temporal lobe with basal extension. Further surgical intervention was performed, completely removing the tumor, which had the same characteristics. The patient is asymptomatic while receiving anticonvulsant therapy (phenytoin) with no evidence of tumor recurrence on MRI after a follow-up of five years. The low grade and soft tissue appearance in images are correlated with the histopathologic and immunohistochemical profile of this tumor, but the rarity of this tumor makes a presumptive diagnosis by images a challenge. The above-mentioned molecular markers or new ones could be used as molecular targets for molecular imaging studies to increase the probability of a pre-operative diagnosis based on molecular features through images.

Acerca de la revista donde se publicó este artículo:

Neuroradiology Journal

Título del artículo:

Primary gliosarcoma of the brain: Radiologic and histopathologic features

Gliosarcoma is a rare central nervous system (CNS) neoplasm with biphasic glial and non-glial malignant components. Here we describe the radiologic and histopathologic features observed in five cases of primary gliosarcoma. The mean age at diagnosis in the studied patients was 54.2 years; these patients were predominantly males (male: female ratio = 4:1). At diagnosis all patients had several clinical deterioration. The most common symptoms of presentation were: headache (5/5 cases), seizures (4/5 cases) and hemiparesis (1/5 cases). All the tumors were large (mean major diameter= 4.12±1.64 cm) at diagnosis as evidenced in computer tomography (CT) scans and magnetic resonance images (MRIs), with preferential involvement of the temporal lobe and frequent associated deviation of the midline structures. Other common characteristics identified on CT scans and MRIs were partial contrast medium uptake with annular pattern (5/5 cases), peripheral edema (5/5 cases), and central calcification (3/5 cases). In additional a peak of dye uptake was observed (4/5 cases) on MRI spectrometry. In the histopathology, the glial component showed malignant astrocytes, with high Ki67 (>60%) and p53 positivity; the sarcomatous components displayed pleomorphic spindle cells similarly with p53 positivity and high Ki67 (75-90%) in all cases. Dedifferentiation to pleomorphic sarcoma (two cases), fibrosarcoma (one case), leiomyosarcoma (one case) and MPNST (one case) were documented. All patients received radiotherapy/chemotherapy and had a median overall survival of ten months. The study of radiologic and histopathologic features in primary gliosarcomas of the brain is a priority to achieve early diagnosis that can be translated to better outcomes. Here we describe the radiologic and histopathologic features observed in a group of gliosarcoma patients with variable histopathologic dedifferentiation.

Acerca de la revista donde se publicó este artículo:

Neuroradiology Journal

Título del artículo:

Ambulatory monitoring of blood pressure versus measurement in the office what is better: The ideal or the possible well done?

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Revista Colombiana de Cardiologia