Título del artículo:

Muscle length, pain, and function in young adults with sacroiliac joint dysfunction

Introduction: Sacroiliac joint dysfunction is a pathomechanical alteration, in which stability is lost and the functioning of the pelvic girdle is altered; the ability to transmit and dissipate forces from the lower limbs to the spine and vice versa is also modified. The shortening of muscles such as the latissimus dorsi, hamstrings and lumbar spinal muscles can alter motor control and generate low back pain. Objective: To evaluate the muscle length of latissimus dorsi, hamstrings and lumbar spinal muscles, pain and functionality in young adults by comparing three study groups: pain, sacroiliac joint dysfunction and control. Methods: A cross-sectional study was carried out. A total of 114 subjects of both sexes were included. Muscle length was assessed through muscle-specific tests. The Visual Analog Scale and the Oswestry were used to measure pain and functionality, respectively. Differences in variables between study groups were calculated with the Chi2 test. Results: No differences in muscle length were observed in the study groups. The group with sacroiliac joint dysfunction presented more individuals with pain and moderate-severe functional limitation. Conclusions: Latissimus dorsi, hamstring and lumbar spinal retractions were not related to low back pain or sacroiliac joint dysfunction; however, young adults in this group presented more discomfort and disability.

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Revista Cubana de Investigaciones Biomedicas

Título del artículo:

ANALYSIS OF THE ENVIRONMENTAL IMPACT OF FUEL HYDROTREATING THROUGH LIFE CYCLE ASSESSMENT AND PROCESS DATA

This document presents an evaluation of the life cycle in the operating scenarios of a diesel hydrotreating (HDT) industrial unit, considering the Eco-Indicator 99 and the process data. First, the process data of the HDT unit were debugged and grouped into operating modes using the kmean algorithm and the silhouette coefficient. The operating modes were then analyzed for their performance differences. Life Cycle Assessment (LCA) was performed for each of the identified modes. According to the results, the statistical analysis of the process data led to the identification of two operating modes (Mode 1 and 2), characterized by their different levels of hydrotreatment severity. Mode 1 represented the higher severity conditions and, therefore, produced a diesel stream with lower sulfur content than that resulting from Mode 2. The LCA showed that the Mode 1 resulted in a greater environmental impact than that derived from Operating Mode 2, due to a higher consumption of industrial utilities and a higher CO2 emission. The H2 consumption and CO2 emission influenced the impacts related to the Natural Resources category, while the electricity consumption influenced the Human Health category. Likewise, the environmental impact levels of the operation of the HDT industrial unit were found to increase by ca 84% in going from the less severe operation to the most severe condition.

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37th International Conference on Efficiency, Cost, Optimization, Simulation and Environmental Impact of Energy Systems, ECOS 2024

Título del artículo:

Recommendations on vaccination in children and adolescents with inborn errors of immunity according to the expanded Colombian immunization program

In this manuscript, we carried out an exhaustive analysis of the global recommendations for immunization in inborn errors of immunity patients. We examined the mechanisms of action and types of vaccines, and we described the vaccines included in the Colombian immunization program together with the specific guidelines for immunization in patients with the most frequent inborn errors of immunity in Colombia. These recommendations were adjusted according to the severity and subclassifications of each immunodeficiency, considering variations in the immune response to offer evidence-based recommendations for vaccination in children with these conditions. We included the most common inborn errors of immunity worldwide and considered the vaccines included in the Colombian immunization program to avoid delays in vaccination schedules. This work was achieved through a narrative, non-systematic review of articles indexed in Spanish and English, using MeSH terms such as: “inborn errors of immunity”, “primary immunodeficiencies”, “vaccination in inborn errors of immunity, “types of vaccines”, “mechanism of action of vaccines”, and “live vaccines in inborn errors of immunity”. We used search engines such as: PubMed, Medline, ScienceDirect, and websites of recognized institutions such as the Centers for Disease Control and Prevention (CDC).

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Biomedica

Título del artículo:

Relationship between Anabolic Steroid Consumption and Mental Health

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Revista del Hospital Psiquiatrico de la Habana

Título del artículo:

Sacha inchi (Plukenetia volubilis L.) husks and seed shells are sources of phenolic compounds with potential health benefits

Sacha inchi (Plukenetia volubilis L.) is an oilseed plant that yields a highly nutritious oil. However, its husks and seed shells are under-utilized byproducts. In this study, ethanolic extracts of sacha inchi husks (SI-husk) and seed shells (SI-shell) were obtained using ultrasound-assisted extraction, evaluating the effects of extraction temperature and solvent-to-solid ratio on the yields. The extracts’ total phenolic contents, phenolic profiles, antioxidant activities, and antimicrobial activities against Gram-positive and Gram-negative bacteria were investigated. Under the selected extraction conditions for SI-husk (60 °C, 1:8 s/s, 280 W, 120 min) and SI-shell (60 °C, 1:3 s/s, 280 W, 120 min), the extracts’ total phenolic contents were 80.18 ± 0.32 and 50.94 ± 0.48 mg GAE (gallic acid equivalents)/g, respectively. Cyanidin, naringenin, and kaempferol were principally found in the SI-husk extract (79.4 %) and vanillic acid in the SI-shell extract (79.9 %). Both extracts exhibited antioxidant activity, with ORAC values of 360.36 ± 0.21 and 228.11 ± 0.14 µmol TE/g, respectively. The antimicrobial activity of the extracts was evaluated against S. aureus, P. aeruginosa, and E. coli using the agar disk diffusion assay. SI-husk (1 mg) exhibited antibacterial activity against Staphylococcus aureus, with an inhibition zone of 10.5 ± 1.8 mm. Our results provide new insights into sacha inchi byproducts as sources of bioactive compounds with potential health benefits.

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Universitas Scientiarum

Título del artículo:

A heart failure program in low-income patients in Argentina (COMM-HF)

Objective. In low-and middle-income countries, heart failure (HF) is the leading cause of death and disability. Materials and methods. A feasibility study was conducted to assess the fidelity, reach, and adoption of an educational program led by non-medical staff to improve outpatient care for patients hospitalized with HF in the local public health system. Results. Thirty patients were included, with a mean age of 55.3 years (63.3% male). A total of 97.3% of planned home visits and 90% of scheduled phone calls were completed. Counselling modules were delivered during 90.4% of home visits, with no significant challenges reported during implementation. At the end of follow-up, there was a trend towards improved lifestyle habits, a reduction in mean heart rate (78.0 to 68.3 beats per minute; p = 0.016), a decrease in the proportion of patients in NYHA functional class III (20% to 7.4%; p = 0.041), and a slight reduction in mean body mass index (29.5 vs. 28.9; p = 0.042). Conclusions. A home-based educational program, designed to optimize outpatient management of heart failure and led by non-medical healthcare personnel, was well-received and demonstrated feasibility for implementation in low-income patients relying solely on the Argentine public health system.

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Archivos Peruanos de Cardiologia y Cirugia Cardiovascular

Título del artículo:

Fragility analysis of a triangular free-form reinforced concrete shell

Considering the importance of deepening the knowledge of the structural behavior of free-form shell structures with a triangular plan, this work presents the results of research on the analysis of seismic vulnerability, verified through linear time-history analysis (NLTHA), generating fragility curves through PSDM models. The analyzes carried out are based on uncertainties regarding both the mechanical properties of the materials and the geometric characteristics of the structures, as well as the action of seismic events. Real accelerograms, compatible with the elastic response spectra for Lisbon and Ouren, Portugal given by the EC8 standard, are used to consider seismic events. In the analyses, fundamental factors are considered, such as the accumulation of damage and the degradation in the resistance of materials. The structure presents highly ductile behavior in the face of seismic loads, attributed to its rigidity, geometry, lightness, and modal behavior, with participation in the horizontal components of the mass in the first five vibration modes greater than 80% and with minimal influence of the vertical component, characteristics inherent to this type of structure. However, it should be noted that the area close to the support, in the same direction as the ground acceleration, is the most vulnerable. This occurs due to the plastic yielding of the concrete during the earthquake, which promotes the appearance of cracks and compression damage. This is verified for the structure when subjected to earthquakes with PGA in the horizontal direction between 0.01 and 0.8 g. The probability of considerable damage increases with seismic events having PGA greater than 0.6 g, which, in turn, can compromise the stability of the structure. It is, therefore, of great importance to study the seismic behavior of shell structures, especially free-form shells, considering the variability and uncertainties related to the structural stress arising from the seismic demand.

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Structural Concrete

Título del artículo:

Thermal and burial history of the axial Arcabuco-Floresta segment, Eastern Cordillera basin, Colombia: evidence from low-temperature thermochronology and numerical modelling

The axial Arcabuco-Floresta segment of the Eastern Cordillera basin, Colombia exhibits a complex geological history characterized by both along and across strike variations in deformation and exhumation, as well as magmatic activity, all of which provide valuable insights into the broader tectono-thermal evolution of the Andean region. In this study, we combine existing thermochronological data, with 16 new zircons (U-Th)/He and 9 new fission-track dates, and numerical modeling to investigate the thermal history in response to such anomalies across the axial Arcabuco-Floresta segment. Single grain ZHe data from Devonian to Lower Cretaceous strata range from 74 to 20 Ma. ZFT data from the same samples show a broader age distribution ranging from 200 to 70 Ma. The integration of different inverse modeling approaches suggests that cooling, here interpreted as exhumation, occurred in three distinct episodes which can each be linked to different regional tectonic interactions since the Late Cretaceous. Over this time, exhumation commenced in the northern and western parts of the basin and extended progressively through to the eastern and southern parts. The first episode, from the Late Cretaceous to Eocene is related to the accretion of different oceanic terranes related to Farallon Plate. The second, from the Oligocene to Middle Miocene, is interpreted as a probable compressional response to accretion of the Panamá-Chocó Arc, Nazca Plate and the Gorgona Terrane. The third, extending from the Middle Miocene to Pleistocene, may be associated with exhumation driven by far-field deformation resulting from the final collision phase of the Panamá-Chocó block with South America and its interaction with the Nazca and Caribbean plates. This last phase led to the complete emergence of the Eastern Cordillera and its development as an orographic barrier. No evidence was found suggesting any possible influence of thermal overprinting on the thermochronological data in the basin.

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Frontiers in Earth Science

Título del artículo:

Face and content validation of the instrument «Awareness, Attitudes, Prevention and Perceptions of COVID-19 Outbreak among Nurses»

Introduction: The care of patients with COVID-19 has generated the need to identify levels of awareness, prevention, attitudes and perception of nursing professionals in intensive care units. The objective of this work was to perform the face and content validation of an instrument of knowledge, attitudes and practices regarding COVID-19. Methodology: Facial validation study of the instrument «Awareness, Attitudes, prevention and perceptions of COVID-19 Outbreak among Nurses» which has 62 questions in four dimensions: knowledge, prevention, attitude and opinion. The Fehring model was used and evaluated taking into account the content validity index (CVI). Results: Eleven experts with postgraduate training and more than 10 years of clinical experience participated. The CVI (< 0.80) and the experts’ comments made it possible to identify 8 items that required revision and 4 were deleted. The validated instrument was made up of 58 items, with 36 in knowledge, 13 in prevention, 5 in attitude and 4 in opinion, and with 4 items requiring reversal for the analysis of the instrument. Conclusions: The instrument showed adequate face and content validity so it can be used for the identification of knowledge, attitudes and practices regarding COVID-19.

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Acta Colombiana de Cuidado Intensivo

Título del artículo:

Muscular strength, endothelial function and cognitive disorders: state of the art

In recent years, the ageing population has increasingly grown. This process carries a range of pathophysiological changes involving alterations in the skeletal muscle, vascular endothelium and brain function, becoming an important risk factor for developing cognitive disorders and cardiovascular diseases. With ageing, there is a decrease in muscle mass and muscle strength, and a relationship between muscle strength decrease and cognitive decline has been shown. Lower handgrip strength has been linked to memory impairment, lower global cognitive function, decreased attention and reduced visuospatial abilities in the elderly, but understanding of the underlying mechanisms that explain the link between altered skeletal muscle function and structure, endothelial dysfunction, and the role of endothelial dysfunction in the onset of cognitive disorders has been scarcely explored. This review aims to detail the cellular and molecular mechanisms by which the progressive changes associated with ageing can alter healthy skeletal muscle and endothelial function, creating an environment of oxidative stress, inflammation and mitochondrial dysfunction. These changes can lead to reduced muscle strength, and the secretion of detrimental endothelial factors, resulting in endothelial dysfunction, blood–brain barrier disruption, and damage to neurons and microglia, ultimately accelerating the onset of cognitive disorders in the elderly. In addition, we aimed to describe the mechanisms that potentially explain how preserving muscular function with resistance training could prevent brain function deterioration, including the production of different factors that allow an improved endothelial function, haemodynamic parameters and brain plasticity, ultimately delaying the onset of cognitive impairment and chronic diseases. (Figure presented.).

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Journal of Physiology

Título del artículo:

Environment and Armed Conflict: Perspectives of Former Combatants of the Revolutionary Armed Forces of Colombia (FARC)

Colombia is home to the longest-running armed conflict in history. This situation has had negative repercussions on various social, economic, political, and environmental aspects. Specifically, this study aimed to analyze the environmental consequences of the armed conflict in Colombia through the interpretation of general notions about the conflict and its link to environmental degradation. To accomplish this task, an exploration of the context was conducted, including the general characteristics of the territory that contributed to the emergence of the conflict, the environmental damages caused during the war, and the main actors involved in the degradation of the territory, based on the perceptions, opinions, experiences, and feelings of former combatants. Information was collected through in-depth interviews. The results focused on understanding the significant elements of the link between the environmental situation and the post-peace agreement period. This study prompts reflection on the indirect implications of war and provides valuable insights for the design and implementation of public policies aimed at preventing environmental deterioration, promoting reconciliation, and improving the living conditions of the affected population.

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Juridicas CUC

Título del artículo:

Microsporogenesis and ultrastructure of pollen grains in Rubus glaucus (Rosaceae)

Introduction: Studies on the microsporogenesis of Rubus glaucus are non-existent and little is known about the ultrastructure of the pollen grains. Objectives: To describe the microsporogenesis process, and ultrastructural aspects of the pollen grains in Rubus glaucus. Methods: Flowers at different developmental stages were embedded in paraffin. Sections were stained with Safranin-Alcian Blue, PAS-Amidoblack and Lacmoid or included in resin and stained with toluidine blue. Ultrathin sections were examined by transmission electron microscopy (TEM). For scanning electron microscopy (SEM) observation, the material was fixed and dehydrated in 2.2 dimethoxypropane, then with Hexamethyldisilazane (HMDS), and the samples were coated with gold. Results: Anthers are differentiated by a cellular mass at the ends distal to the staminal filaments. During development, the anther wall presents several cellular layers and at maturity, they are reduced to the epidermis and the endothecium. Microsporocytes undergo simultaneous meiosis and form tetrahedral tetrads. The tapetum develops secretory activity until pollen grains are released, then the cellular content undergoes autolysis. During sporodermis formation, the exine is first deposited and then the intine in a centripetal form. The pollen grains are tricolporate, isopolar, oblate to peroblate, with radial simetry, circular in outline with blunt apices in polar view, ellipsoidal in equatorial view. The exine is thick, tectated, striate perforate. The sporodermis presents an ectexine formed by a tectum interrupted by perforations and thick columellae. Colpus membrane presents small exine granules and orbicules on the surface. The intine develops known structural patterns. Pollenkitt is inconspicuous. Conclusion: Anthers structure and development follows the known patterns of angiosperms. Simultaneous microsporogenesis and centripetal deposition of the sporodermis, as well as ornamentation patterns, have been previously described for the Rosaceae Family.

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Revista de Biologia Tropical

Título del artículo:

Cryptococcal Meningitis in an HCV-Positive and IVDU-and HIV-Negative Patient: A Case Report and Literature Review

Background: Cryptococcal meningitis (CM) is a central nervous system (CNS) infection that occurs mainly in immunocompromised individuals such as those with human immunodeficiency virus (HIV) infection. However, the prevalence of CM in immunocompetent patients has increased. Although CM has been reported in patients with hepatitis C virus (HCV) infection, it has not yet been fully established whether there is an association between both conditions. CM has also been reported in patients with intravenous drug use (IVDU), which is related to the immunosuppression caused by these drugs. Case Presentation: We report the case of a 24-year-old man who presented with meningitis secondary to Cryptococcus gattii infection. He had a history of IVDU and HCV infection, was HIV-negative and without antiviral treatment. The patient received adequate antifungal treatment during induction, consolidation, and maintenance phases. His condition relapsed, requiring dose adjustment, with an excellent response during clinical follow-up for both meningitis and HCV infection. A brain biopsy was requested during relapse to rule out other co-infection. Conclusion: The case of an individual diagnosed with cryptococcal meningitis, who had a history of IVDU and HCV infection, is presented. The coexistence of such events could shadow the prognosis of this group of subjects, related to immunosuppression that can be caused through different pathways. Having HCV and being a IVDU simultaneously could increase the risk of Cryptococcus infection.

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International Medical Case Reports Journal

Título del artículo:

Communication with Health Personnel and Human Rights: A Perspective from People with Mental Disorders

Mental health care has focused on participation, which, in addition to improving recovery processes, constitutes a tool to defend the human rights of people with mental disorders. For this participation, communication is a fundamental element. The objective of the present research was to analyzed the perception of the human rights and communication with healthcare personnel in care processes, from leaders of mutual aid groups or support groups in various contexts of Colombia. It is expected that the generated information can contribute to the evaluation of the quality of mental health services from a human rights and health participation perspective, in contexts similar to the one being analyzed. A qualitative approach has been used, which takes information from six leaders of support groups for mental health, in four regions of Colombia. Said information was analyzed through a thematic analysis, contrasting with the vision of the researchers and with the current theory. It is found that the subject of communication was made up of categories such as Previous ineffective treatments and Perception of a violation of dignity. Communication barriers are pointed out, such as attitudes of mental health professionals, but the influence that the health system and social and political barriers can have on the same communication is recognized. From the perception of leaders of mental health support groups, it is concluded that it is necessary to improve aspects of communication in health personnel. In addition, clinical mental health care could also be a space for the promotion of human rights.

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Journal of Psychosocial Rehabilitation and Mental Health

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Changes in ruminal fermentation and rumen bacteria population in feedlot cattle during a high lipid diet adaptation

This study aimed to investigate changes in feed intake and ruminal environmental parameters during a high-lipid diet transition in cattle. Eight Nellore steers were fed a control diet composed of 30% hay and 70% concentrate for 21 days, followed by the inclusion of 60 g/kg dry matter of soybean oil for 21 days. The DM intake expressed as a percentage of BW 21 days after lipid inclusion was lower (1.75% BW) than that observed during the control diet feeding (1.81% BW) (P<0.01). Steers fed the control diet had a lower pH than the ruminal pH recorded on days 7, 14, and 21 after lipid inclusion (P=0.034). Lower total short-chain fatty acid production in the rumen and lower microbial nitrogen synthesis were observed on day 7 after lipid inclusion compared to values found when steers were fed the control diet and on days 14 and 21 after lipid inclusion (P=0.041). Lipid inclusion in the diet decreased the population of protozoa on days 7, 14, and 21 (P<0.001). The abundances of R. albus and F. succinogenes were higher when steers were fed the control diet than the abundance observed on days 7, 14, and 21 after lipid inclusion in the diet (P<0.05). The first seven days of lipid diet inclusion are considered the most critical for ruminal adaptation, involving reductions in fibrolytic bacteria and changes in fermentation parameters. After 14 days the rumen showed signs of recovery and adaptation.

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Animal Science Papers and Reports

Título del artículo:

Butterflies (Lepidoptera: Papilionoidea), honeybees (Hymenoptera: Apidae) and dung beetles (Coleoptera: Scarabaeidae) of three vegetable covers on Convención, Norte de Santander, Colombia

Objective: To report the butterflies, honeybees and dung beetles of three vegetable covers on Convencion (Norte de Santander, Colombia). Scope: Introduce a list of species of butterflies, honeybees and dung beetles of study zone. Methodology: butterflies were collected using entomological nets and Van Someren-Rydon traps baited with a mixture of fermented fruit. For the collection of bees, carpotraps with essences (eucalyptol and methyl salicylate) and active collection with entomological nets on flowers were used. The dung beetles were collected using pitfall traps baited with a mixture of pig manure and human dung. Main results: A total of 262 butterflies belonging to 78 species were collected, the most abundant were Hermeuptychia hermes (23), Abaeis albula (17) and Pyrisitia venusta (14); 261 bees belonging to 21 species were collected, being Eulaema flavescens (47) and Euglossa aff. iopyrrha (36) the most abundant; and 1735 dung beetles belonging to 24 species were collected. Conclusions: The butterflies collected correspond to widely distributed species and most are typical of open and fragmented areas. About bees, some recorded species of Euglossa and Eulaema often to frequent both conserved areas and disturbed areas, but the abundance decrease according to the plant cover. Regarding dung beetles collect, which less than half were found in the three covers, showing their tolerance to different degrees of intervention. These data become an important contribution to an unexplored area.

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Boletin Cientifico del Centro de Museos

Título del artículo:

Varicella pneumonia in an immunocompetent adult patient: Case report and review of the literature

Varicella is a childhood disease characterized by its self-limiting and benign nature. However, it can also affect the adult population due to risk factors, leading to infection with numerous complications involving the central nervous system, kidneys, respiratory system, and skin. Varicella pneumonia, one of the most feared complications in adults, occurs in approximately 1 out of 400 patients with the disease. This complication primarily affects male patients with a history of heavy smoking and immunosuppression, either due to an underlying disease such as HIV and cancer, drug use, pregnancy or pulmonary disease. It is recommended that this complication should be treated with intravenous acyclovir at a dose of 10 mg/kg/8 hours. The prognosis depends on the development of respiratory failure; up to 50 % of patients with this complication require invasive mechanical ventilation. Here, we report the clinical case of an immunocompetent patient with a typical presentation of varicella that rapidly progressed to a respiratory infection requiring antiviral treatment and invasive mechanical ventilation.

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Respiratory Medicine Case Reports

Título del artículo:

Scaling Scientific Knowledge Discovery with Neuro-Symbolic AI and Large Language Models

The increasing amount of available research data leads to the need to scale scientific knowledge discovery, e.g., the conduction of systematic literature reviews (SLRs), to keep up with fast developments in research and further support decision-making in the industry.AI-based methods are gaining importance in these tasks and have been integrated into many SLR tools.Yet, several challenges are still open on applying especially neural methods on scientific knowledge discovery tasks.To address this, we evaluate various neural and neuro-symbolic scenarios on a specific generative writing task.While confirming existing concerns on pure Large Language Model (LLM) approaches for these tasks, we obtain a heterogeneous picture of Retrieval-Augmented Generation (RAG) approaches.The most promising candidate is a Knowledge Graph (KG) based context-enhanced LLM approach for Knowledge Discovery.

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CEUR Workshop Proceedings

Título del artículo:

Impact of COVID-19 on Mental Health in Latin America

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Revista del Hospital Psiquiatrico de la Habana

Título del artículo:

Evolution and Trends in Digital Skills and Graduate Employability: Bibliometric Analysis

In today\'s digital age, acquiring digital skills is critical to success in the labour market, highlighting the urgency for educational institutions to integrate these skills into their academic programmes. Although the importance of this issue is recognised, a comprehensive assessment that merges quantitative and qualitative analyses on the subject is still lacking. Responding to this need, this study analyzes the scientific production on digital skills and employability of graduates, through a bibliometric analysis of publications in Scopus from 2015 to 2023. 24 relevant documents were identified, with Europe leading in scientific production and 2022 as the most productive year. Torres-Corona stands out as the most cited author, illustrating his influence in the field. The predominant topics focus on higher education, methodology and evaluation, professional challenges and the practical application of digital skills. These results underline the importance of evolving educational strategies to meet the demands of the digital labour market, providing key perspectives for future research and educational policy development.

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Proceedings of the LACCEI international Multi-conference for Engineering, Education and Technology

Título del artículo:

Factors associated with anxious and depressive symptomatology and religiosity in breast cancer patients

Objective: To explore the association of clinical and demographic factors with anxious and depressive symptoms and religiosity in patients diagnosed with breast cancer undergoing initial chemotherapy treatment. Methods: Observational, analytical, and cross-sectional study. There was the participation of 42 women undergoing chemotherapy treatment for the first time for breast cancer. The HADS scales were used to measure anxious symptoms, the PHQ9 for anxiety symptoms, and the Francis 4 for religiosity. Descriptive and bivariate analysis was performed. Results: Symptoms of anxiety and depression with clinical significance occurred in 45.2% and 14.3% respectively, and 14.3% of patients had high religiosity. Conclusions: A direct and significant correlation was found between depression scores with religiosity scores. patients with clinically significant depressive symptoms are more likely to have high religiosity.

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Index de Enfermeria

Título del artículo:

Optimising production scheduling decisions in flowshop manufacturing cells for a sportswear manufacturing case

This paper aims to reduce makespan and total weighted tardiness (TWT) by applying a cellular manufacturing system (CMS) approach based on formulations for the flowshop group-scheduling problem (FSGSP) to the sewing area of a sportswear manufacturing company in Colombia. The main contribution of this paper is the application of recent FSGSP models to a novel case study in the apparel industry. As part of the methodology, two FSGSP models framed in a CMS environment were proposed based on the literature review. In addition, a genetic algorithm (GA) was developed to evaluate this application in terms of makespan and TWT. The results showed that the proposed approach completely reduced the total tardiness penalty costs and 56.23% for makespan compared to the current state. These results seek to promote the application of models and techniques for addressing the lack of productivity, high waste, and customer dissatisfaction in this Colombian industry.

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International Journal of Advanced Operations Management

Título del artículo:

Development and Implementation of a Safety Incident Report System for Health Care Discipline Students During Clinical Internships: Observational Study

Background: Patient safety is a fundamental aspect of health care practice across global health systems. Safe practices, which include incident reporting systems, have proven valuable in preventing the recurrence of safety incidents. However, the accessibility of this tool for health care discipline students is not consistent, limiting their acquisition of competencies. In addition, there is no tools to familiarize students with analyzing safety incidents. Gamification has emerged as an effective strategy in health care education. Objective: This study aims to develop an incident reporting system tailored to the specific needs of health care discipline students, named Safety Incident Report System for Students. Secondary objectives included studying the performance of different groups of students in the use of the platform and training them on the correct procedures for reporting. Methods: This was an observational study carried out in 3 phases. Phase 1 consisted of the development of the web-based platform and the incident registration form. For this purpose, systems already developed and in use in Spain were taken as a basis. During phase 2, a total of 223 students in medicine and nursing with clinical internships from universities in Argentina, Brazil, Colombia, Ecuador, and Spain received an introductory seminar and were given access to the platform. Phase 3 ran in parallel and involved evaluation and feedback of the reports received as well as the opportunity to submit the students’ opinion on the process. Descriptive statistics were obtained to gain information about the incidents, and mean comparisons by groups were performed to analyze the scores obtained. Results: The final form was divided into 9 sections and consisted of 48 questions that allowed for introducing data about the incident, its causes, and proposals for an improvement plan. The platform included a personal dashboard displaying submitted reports, average scores, progression, and score rankings. A total of 105 students participated, submitting 147 reports. Incidents were mainly reported in the hospital setting, with complications of care (87/346, 25.1%) and effects of medication or medical products (82/346, 23.7%) being predominant. The most repeated causes were related confusion, oversight, or distractions (49/147, 33.3%) and absence of process verification (44/147, 29.9%). Statistically significant differences were observed between the mean final scores received by country (P<.001) and sex (P=.006) but not by studies (P=.47). Overall, participants rated the experience of using the Safety Incident Report System for Students positively. Conclusions: This study presents an initial adaptation of reporting systems to suit the needs of students, introducing a guided and inspiring framework that has garnered positive acceptance among students. Through this endeavor, a pathway toward a safety culture within the faculty is established. A long-term follow-up would be desirable to check the real benefits of using the tool during education.

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JMIR Medical Education

Título del artículo:

Clindamycin plus oxacillin, is this combination useful?

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Gaceta Medica Boliviana

Título del artículo:

In vitro and in silico analyses of Lippia alba (Verbenaceae) essential oil as an inhibitor of dengue virus and platelet activation

Dengue virus (DENV) causes millions of infections each year, and there are currently no approved antivirals. Essential oils could serve as potential candidates for developing plant-based dengue treatments. Lippia alba (Mill.) N.E. Brown essential oil (LAEO) was selected to investigate the mode of antiviral action and its effect on activated platelets. Binding affinities of 20 LAEO compounds and platelet proteins were investigated through docking analyses. LAEO showed a potent virucidal effect (IC50, 2.1 to 5.1 μg/mL) against all DENV serotypes. LAEO reduced P-selectin (from 61% to 18%) and increased survival (from 71% to 97%) in DENV-2- and DENV NS1-stimulated human platelets. Sesquiterpene hydrocarbons showed the highest binding affinities (from −7.3 to −8.0 kcal/mol) with platelet innate immune receptors such as TLR2/1, TLR4/MD-2 and αIIbβ3 integrin. The data provide a first step towards defining the potential of LAEO as a candidate for developing phytotherapeutics for dengue.

Acerca de la revista donde se publicó este artículo:

Journal of Essential Oil Research